Pre- and postnatal exposure of mice to concentrated urban PM2.5 decreases the number of alveoli and leads to altered lung function at an early stage of life

• Published in: Environmental pollution (1987) Vol. 241; pp. 511 - 520
• Main Authors: de Barros Mendes Lopes, Thais, Groth, Espen E., Veras, Mariana, Furuya, Tatiane K., de Souza Xavier Costa, Natalia, Ribeiro Júnior, Gabriel, Lopes, Fernanda Degobbi, de Almeida, Francine M., Cardoso, Wellington V., Saldiva, Paulo Hilario Nascimento, Chammas, Roger, Mauad, Thais
• Format: Journal Article
• Language: English
• Published: Elsevier Ltd 01.10.2018
• Subjects: adults; air; Air pollution; Alveolarization; Brazil; cell proliferation; children; DNA damage; fetus; gene expression regulation; inflammation; Lung development; lung function; lungs; mice; neonates; Particulate matter; particulates; pregnancy; Transcriptomics; Brazil; Air pollution; Lung development; Alveolarization; Transcriptomics; Particulate matter

Gestational exposure to air pollution is associated with negative outcomes in newborns and children. In a previous study, we demonstrated a synergistic negative effect of pre- and postnatal exposure to PM2.5 on lung development in mice. However, the means by which air pollution affects development o...