Low dietary inclusion of nutraceuticals from microalgae improves feed efficiency and modifies intermediary metabolisms in gilthead sea bream (Sparus aurata)

• Published in: Scientific reports Vol. 10; no. 1; p. 18676
• Main Authors: Perera, Erick, Sánchez-Ruiz, David, Sáez, María Isabel, Galafat, Alba, Barany, André, Fernández-Castro, Miriam, Vizcaíno, Antonio Jesús, Fuentes, Juan, Martínez, Tomás Francisco, Mancera, Juan Miguel, Alarcón, Francisco Javier, Martos-Sitcha, Juan Antonio
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 29.10.2020; Nature Publishing Group
• Subjects: 631/443; 631/45; 631/45/607; 631/601/1737; 631/601/2722; 692/700/2814; Algae; Animal behavior; Animal Feed; Animals; Aquaculture; Aquatic microorganisms; Cortisol; Diet; Dietary Supplements; Efficiency; Fatty acids; Feed conversion; Feed efficiency; Feeds; Functional foods & nutraceuticals; Gluconeogenesis; Glycogen; Growth rate; Humanities and Social Sciences; Lactic acid; Linolenic acid; Liver; Metabolites; Microalgae; Microalgae - chemistry; multidisciplinary; Physical growth; Science; Science (multidisciplinary); Sea Bream - metabolism; Sparus aurata
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-020-75693-3

The aim of this work was to evaluate two functional feeds for the gilthead seabream, Sparus aurata , containing low inclusion of two microalgae-based products (LB-GREENboost, LB Gb ; and LB-GUThealth, LB Gh ). Fish (12–13 g) were fed for 13 weeks a control diet or one of the four diets supplemented with both products at 0.5% or 1%. LB Gb and LB Gh did not affect specific growth rate or survival, but increased feed efficiency by decreasing feed intake and enlarging the intestines. LB Gb increased hepatosomatic index and reduced cortisol levels in plasma, while both products lowered plasma lactate. Extensive metabolite and metabolic enzyme profiling revealed that microalgae supplementations, especially 1% LB Gh : (i) decrease plasma lactate and increase hepatic glycogen, (ii) reduce hepatic gluconeogenesis, (iii) enhance hepatic lipogenic activity and lipid secretion, (iv) led fish to double triglyceride content in muscle and to stimulate its lipid oxidative capacity, and (v) increase the content of monounsaturated fatty acids and the omega-3 alpha-linolenic acid in muscle. This study demonstrates that both microalgae-based products are suited to improve feed efficiency and orchestrate significant changes in the intermediary metabolism in gilthead seabream juveniles.