Subcellular localization and distribution of the reduced folate carrier in normal rat tissues

• Published in: European journal of histochemistry Vol. 55; no. 1; p. e3
• Main Authors: Hinken, M, Halwachs, S, Kneuer, C, Honscha, W
• Format: Journal Article
• Language: English
• Published: Italy PAGEPress Publications 27.01.2011
• Subjects: Animals; cancer; Cells, Cultured; chemotherapy; Dogs; Electrophoresis, Polyacrylamide Gel; folate homeostasis; Gene Expression Regulation; Immunohistochemistry; Kidney - chemistry; Kidney - cytology; Kidney - metabolism; Male; methotrexate; Original Paper; Rabbits; Rats; Rats, Sprague-Dawley; Reduced folate carrier; Reduced Folate Carrier Protein - chemistry; Reduced Folate Carrier Protein - genetics; Reduced Folate Carrier Protein - metabolism; Reverse Transcriptase Polymerase Chain Reaction; Tissue Distribution

The reduced folate carrier (Rfc1; Slc19a1) mediated transport of reduced folates and antifolate drugs such as methotrexate (MTX) play an essential role in physiological folate homeostasis and MTX cancer chemotherapy. As no systematic reports are as yet available correlating Rfc1 gene expression and...