Mesolimbic Dopamine Super-Sensitivity in Melanin-Concentrating Hormone-1 Receptor-Deficient Mice

• Published in: The Journal of neuroscience Vol. 25; no. 4; pp. 914 - 922
• Main Authors: Smith, Daniel G, Tzavara, Eleni T, Shaw, Janice, Luecke, Susan, Wade, Mark, Davis, Richard, Salhoff, Craig, Nomikos, George G, Gehlert, Donald R
• Format: Journal Article
• Language: English
• Published: United States Soc Neuroscience 26.01.2005; Society for Neuroscience
• Subjects: 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine - pharmacology; Animals; Behavioral/Systems/Cognitive; Dextroamphetamine - pharmacology; Dopamine - metabolism; Dopamine - physiology; Dopamine Agonists - pharmacology; Limbic System - physiology; Male; Membrane Transport Proteins - metabolism; Mesencephalon - physiology; Mice; Mice, Knockout; Motor Activity - drug effects; Motor Activity - physiology; Neural Pathways - physiology; Norepinephrine - metabolism; Nucleus Accumbens - metabolism; Quinpirole - pharmacology; Receptors, Dopamine - metabolism; Receptors, Somatostatin - genetics; Receptors, Somatostatin - physiology; Serotonin - metabolism

Melanin-concentrating hormone (MCH) neurons and MCH-1 receptors (MCH1r) densely populate mesolimbic dopaminergic brain regions such as the nucleus accumbens (NAc). The regulation of dopamine by MCH1r was suggested to be an important mechanism underlying the hyperactive phenotype of MCH1r knock-out (...