Human embryonic stem cells contribute to embryonic and extraembryonic lineages in mouse embryos upon inhibition of apoptosis

Dear Editor, Recently, interspecies chimera formation has been established in rodents by injection of rat pluripotent stem cells （PSCs） into mouse early embryos, and such a system provides an in vivo assay to test the developmental potential of human PSCs （hPSCs） [1]. In addition, the interspecies c...

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Published inCell research Vol. 28; no. 1; pp. 126 - 129
Main Authors Wang, Xuepeng, Li, Tianda, Cui, Tongtong, Yu, Dawei, Liu, Chao, Jiang, Liyuan, Feng, Guihai, Wang, Lei, Fu, Rui, Zhang, Xinxin, Hao, Jie, Wang, Yukai, Wang, Liu, Zhou, Qi, Li, Wei, Hu, Baoyang
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.01.2018
Nature Publishing Group
Subjects
631/136/2444
631/136/532/2117
631/80/82/23
631/80/86
Apoptosis
Biomedical and Life Sciences
Cell Biology
Embryo cells
Embryos
Letter to the Editor
Life Sciences
Stem cell transplantation
Stem cells
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Summary:Dear Editor, Recently, interspecies chimera formation has been established in rodents by injection of rat pluripotent stem cells （PSCs） into mouse early embryos, and such a system provides an in vivo assay to test the developmental potential of human PSCs （hPSCs） [1]. In addition, the interspecies chimeras formed between hPSCs and large animal embryos would open new avenues to generate human tissues and organs for regenerative medicine [2]. In rodents, embryonic stem cells （ESCs） and epiblast stem cells （EpiSCs） have been derived from inner cell mass （ICM） of the blastocyst and post-implantation epiblast respectively [3, 4].
Bibliography:31-1568
Human embryonic stem ;cells contribute
Dear Editor, Recently, interspecies chimera formation has been established in rodents by injection of rat pluripotent stem cells （PSCs） into mouse early embryos, and such a system provides an in vivo assay to test the developmental potential of human PSCs （hPSCs） [1]. In addition, the interspecies chimeras formed between hPSCs and large animal embryos would open new avenues to generate human tissues and organs for regenerative medicine [2]. In rodents, embryonic stem cells （ESCs） and epiblast stem cells （EpiSCs） have been derived from inner cell mass （ICM） of the blastocyst and post-implantation epiblast respectively [3, 4].
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These five authors contributed equally to this work.
ISSN:1001-0602
1748-7838
1748-7838
DOI:10.1038/cr.2017.138