Dosing Patterns for Duloxetine and Predictors of High-Dose Prescriptions in Patients With Major Depressive Disorder: Analysis from a United States Third-Party Payer Perspective

• Published in: Clinical therapeutics Vol. 33; no. 11; pp. 1726 - 1738
• Main Authors: Liu, Xianchen, Cui, Zhanglin, Niu, Liyuan, Faries, Douglas E., Ball, Tamara, Johnstone, Bryan
• Format: Journal Article
• Language: English
• Published: Bridgewater, NJ EM Inc USA 01.11.2011; Elsevier; Elsevier Limited
• Subjects: Adult; Adult and adolescent clinical studies; Antidepressants; Antidepressive Agents - therapeutic use; Biological and medical sciences; Clinical trials; Costs; Depression; Depressive Disorder, Major - drug therapy; Dose-Response Relationship, Drug; dosing patterns; duloxetine; Duloxetine Hydrochloride; Ethnicity; Female; high-dose; Humans; Illnesses; Insurance claims; Internal Medicine; major depressive disorder; Male; Medical Education; Medical sciences; Middle Aged; Mood disorders; Multivariate Analysis; Pharmacology. Drug treatments; Prescriptions; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Substance abuse treatment; Thiophenes - administration & dosage; Thiophenes - therapeutic use; treatment; United States; United States; North America; America; United States > US; treatment; duloxetine; high-dose; major depressive disorder; dosing patterns; Mood disorder; Human; Serotonin; Psychotropic; Depression; Duloxetine; Catecholamine; Reuptake inhibitor; Posology; Treatment; Medical prescription; Neurotransmitter; Antidepressant agent; Norepinephrine; Predictive factor; High dose

Major depressive disorder (MDD) is a common illness that affects ∼7% of adults in the United States each year. Duloxetine is a dual reuptake inhibitor of serotonin and norepinephrine that has demonstrated efficacy and tolerability in the treatment of MDD. The purpose of our study was to examine dosi...