Daphnetin protects oxidative stress-induced neuronal apoptosis via regulation of MAPK signaling and HSP70 expression

• Published in: Oncology letters Vol. 12; no. 3; pp. 1959 - 1964
• Main Authors: Qi, Zhilin, Qi, Shimei, Gui, Lin, Shen, Lei, Feng, Zunyong
• Format: Journal Article
• Language: English
• Published: Greece D.A. Spandidos 01.09.2016; Spandidos Publications; Spandidos Publications UK Ltd
• Subjects: Alzheimer's disease; Antioxidants; Apoptosis; Cellular signal transduction; daphnetin; Gene expression; Genetic aspects; Health aspects; Heat shock proteins; HSP70; Immunoglobulins; Infrared imaging systems; Kinases; MAPK; Morphology; Oncology; Oxidative stress; Parkinson's disease; Phosphorylation; Plant products; Properties; Protein kinases; Proteins; Signal transduction; United States > US; daphnetin; apoptosis; HSP70; MAPK; oxidative stress

Neurodegenerative disorders are characterized by progressive degeneration and loss of neurons in the brain. Oxidative stress is implicated in the pathogenesis of neurological disorders, although the pathological mechanism remains unelucidated. Daphnetin, an active ingredient extracted from Changbai...