BCAT2-mediated BCAA catabolism is critical for development of pancreatic ductal adenocarcinoma

• Published in: Nature cell biology Vol. 22; no. 2; pp. 167 - 174
• Main Authors: Li, Jin-Tao, Yin, Miao, Wang, Di, Wang, Jian, Lei, Ming-Zhu, Zhang, Ye, Liu, Ying, Zhang, Lei, Zou, Shao-Wu, Hu, Li-Peng, Zhang, Zhi-Gang, Wang, Yi-Ping, Wen, Wen-Yu, Lu, Hao-Jie, Chen, Zheng-Jun, Su, Dan, Lei, Qun-Ying
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.02.2020; Nature Publishing Group
• Subjects: 13/1; 13/109; 13/51; 13/89; 631/67; 631/67/1504/1713; 64/110; 64/60; 692/699/67/2327; Adenocarcinoma; Adenocarcinoma - genetics; Adenocarcinoma - metabolism; Adenocarcinoma - pathology; Adult; Amino acids; Amino Acids, Branched-Chain - metabolism; Amino Acids, Branched-Chain - pharmacology; Analysis; Animal models; Animals; Bases (nucleic acids); Biomedical and Life Sciences; Branched chain amino acids; Cancer Research; Carcinogenesis - genetics; Carcinogenesis - metabolism; Carcinogenesis - pathology; Carcinoma, Pancreatic Ductal - genetics; Carcinoma, Pancreatic Ductal - metabolism; Carcinoma, Pancreatic Ductal - pathology; Catabolism; Cell Biology; Cell Line, Tumor; Chain branching; Chains; Clonal deletion; Development and progression; Developmental Biology; Disease Progression; Female; Gene Expression Regulation, Neoplastic; Heterografts; Humans; Inhibitors; Isoenzymes - genetics; Isoenzymes - metabolism; K-Ras protein; Keto Acids - metabolism; Keto Acids - pharmacology; Kinases; Lethality; Letter; Life Sciences; Lung cancer; Lung cancer, Non-small cell; Lung carcinoma; Male; Metabolic pathways; Mice; Mice, Transgenic; Middle Aged; Minor Histocompatibility Antigens - genetics; Minor Histocompatibility Antigens - metabolism; Mitochondria; Mutation; Organoids; Organoids - drug effects; Organoids - metabolism; Organoids - pathology; Pancreas; Pancreatic cancer; Pancreatic Ducts - drug effects; Pancreatic Ducts - metabolism; Pancreatic Ducts - pathology; Pancreatic Neoplasms - genetics; Pancreatic Neoplasms - metabolism; Pancreatic Neoplasms - pathology; Pregnancy Proteins - genetics; Pregnancy Proteins - metabolism; Protein-tyrosine kinase; Proto-Oncogene Proteins p21(ras) - genetics; Proto-Oncogene Proteins p21(ras) - metabolism; Resveratrol; Ribonucleoproteins - genetics; Ribonucleoproteins - metabolism; Scientific equipment and supplies industry; Signal Transduction; Spleen; Stem Cells; Syk Kinase - genetics; Syk Kinase - metabolism; Syk protein; Transaminase; Transaminases - genetics; Transaminases - metabolism; Tyrosine; Ubiquitin-protein ligase; United States; China

Branched-chain amino acid (BCAA) metabolism is potentially linked with development of pancreatic ductal adenocarcinoma (PDAC) 1 - 4 . BCAA transaminase 2 (BCAT2) was essential for the collateral lethality conferred by deletion of malic enzymes in PDAC and the BCAA–BCAT metabolic pathway contributed...