The Gut Microbiome and Metabolomics Profiles of Restricting and Binge-Purging Type Anorexia Nervosa

Alterations in the gut microbiome and fecal metabolites have been detected in anorexia nervosa (AN), but differences in those profiles between restricting AN (ANR) and binge-purging AN (ANBP) type have not been explored. We made a secondary analysis of our previous data concerning microbiome and met...

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Published inNutrients Vol. 13; no. 2; p. 507
Main Authors Monteleone, Alessio Maria, Troisi, Jacopo, Serena, Gloria, Fasano, Alessio, Dalle Grave, Riccardo, Cascino, Giammarco, Marciello, Francesca, Calugi, Simona, Scala, Giovanni, Corrivetti, Giulio, Monteleone, Palmiero
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.02.2021
MDPI
Subjects
Adult
Anorexia
Anorexia nervosa
Anorexia Nervosa - microbiology
Anorexia Nervosa - physiopathology
Behavior
binge-purging anorexia nervosa
Comparative analysis
Diagnosis
Diet
Digestive system
Discriminant analysis
Dysbacteriosis
Eating disorders
fecal metabolomics
Feces
Feces - microbiology
Female
Gastrointestinal Microbiome - physiology
gut microbiome
Humans
Intestinal microflora
Laxatives
Lipids
Mental disorders
Metabolism
Metabolites
Metabolomics
Metabolomics - methods
Microbiomes
Microbiota
Microorganisms
Physiology
restricting anorexia nervosa
Secondary analysis
Software
Womens health
Young Adult
United States > US
Italy
gut microbiome
eating disorders
fecal metabolomics
binge-purging anorexia nervosa
restricting anorexia nervosa
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Abstract Alterations in the gut microbiome and fecal metabolites have been detected in anorexia nervosa (AN), but differences in those profiles between restricting AN (ANR) and binge-purging AN (ANBP) type have not been explored. We made a secondary analysis of our previous data concerning microbiome and metabolomics profiles of 17 ANR women, six ANBP women and 20 healthy controls (HC). Twelve fecal metabolites differentiating ANR patients, ANBP patients and HC were identified. Both patient groups showed decreased intra-individual bacterial richness with respect to healthy controls (HC). Compared to ANR subjects, ANBP patients had a significant increase in relative abundances of , Bifidobacteriaceae, Bifidobacteriales, and Eubacteriacae and a significant decrease in relative abundances of , , Pasteurellaceae, and Pasteurellales. The heatmaps of the relationships of selected fecal metabolites with microbial families showed different structures among the three groups, with the heatmap of ANBP patients being drastically different from that of HC, while that of ANR patients resulted more similar to HC. These findings, although preliminary because of the relatively small sample size, confirm the occurrence of different gut dysbiosis in ANR and ANBP and demonstrate different connections between gut microorganisms and fecal metabolites in the two AN types.
AbstractList Alterations in the gut microbiome and fecal metabolites have been detected in anorexia nervosa (AN), but differences in those profiles between restricting AN (ANR) and binge-purging AN (ANBP) type have not been explored. We made a secondary analysis of our previous data concerning microbiome and metabolomics profiles of 17 ANR women, six ANBP women and 20 healthy controls (HC). Twelve fecal metabolites differentiating ANR patients, ANBP patients and HC were identified. Both patient groups showed decreased intra-individual bacterial richness with respect to healthy controls (HC). Compared to ANR subjects, ANBP patients had a significant increase in relative abundances of Bifidobacterium , Bifidobacteriaceae, Bifidobacteriales, and Eubacteriacae and a significant decrease in relative abundances of Odoribacter , Haemophilus , Pasteurellaceae, and Pasteurellales. The heatmaps of the relationships of selected fecal metabolites with microbial families showed different structures among the three groups, with the heatmap of ANBP patients being drastically different from that of HC, while that of ANR patients resulted more similar to HC. These findings, although preliminary because of the relatively small sample size, confirm the occurrence of different gut dysbiosis in ANR and ANBP and demonstrate different connections between gut microorganisms and fecal metabolites in the two AN types.
Alterations in the gut microbiome and fecal metabolites have been detected in anorexia nervosa (AN), but differences in those profiles between restricting AN (ANR) and binge-purging AN (ANBP) type have not been explored. We made a secondary analysis of our previous data concerning microbiome and metabolomics profiles of 17 ANR women, six ANBP women and 20 healthy controls (HC). Twelve fecal metabolites differentiating ANR patients, ANBP patients and HC were identified. Both patient groups showed decreased intra-individual bacterial richness with respect to healthy controls (HC). Compared to ANR subjects, ANBP patients had a significant increase in relative abundances of , Bifidobacteriaceae, Bifidobacteriales, and Eubacteriacae and a significant decrease in relative abundances of , , Pasteurellaceae, and Pasteurellales. The heatmaps of the relationships of selected fecal metabolites with microbial families showed different structures among the three groups, with the heatmap of ANBP patients being drastically different from that of HC, while that of ANR patients resulted more similar to HC. These findings, although preliminary because of the relatively small sample size, confirm the occurrence of different gut dysbiosis in ANR and ANBP and demonstrate different connections between gut microorganisms and fecal metabolites in the two AN types.
Alterations in the gut microbiome and fecal metabolites have been detected in anorexia nervosa (AN), but differences in those profiles between restricting AN (ANR) and binge-purging AN (ANBP) type have not been explored. We made a secondary analysis of our previous data concerning microbiome and metabolomics profiles of 17 ANR women, six ANBP women and 20 healthy controls (HC). Twelve fecal metabolites differentiating ANR patients, ANBP patients and HC were identified. Both patient groups showed decreased intra-individual bacterial richness with respect to healthy controls (HC). Compared to ANR subjects, ANBP patients had a significant increase in relative abundances of Bifidobacterium, Bifidobacteriaceae, Bifidobacteriales, and Eubacteriacae and a significant decrease in relative abundances of Odoribacter, Haemophilus, Pasteurellaceae, and Pasteurellales. The heatmaps of the relationships of selected fecal metabolites with microbial families showed different structures among the three groups, with the heatmap of ANBP patients being drastically different from that of HC, while that of ANR patients resulted more similar to HC. These findings, although preliminary because of the relatively small sample size, confirm the occurrence of different gut dysbiosis in ANR and ANBP and demonstrate different connections between gut microorganisms and fecal metabolites in the two AN types.
Audience Academic
Author Marciello, Francesca
Monteleone, Alessio Maria
Calugi, Simona
Scala, Giovanni
Cascino, Giammarco
Monteleone, Palmiero
Dalle Grave, Riccardo
Serena, Gloria
Troisi, Jacopo
Fasano, Alessio
Corrivetti, Giulio
AuthorAffiliation 1 Department of Psychiatry, University of Campania “Luigi Vanvitelli”, 80138 Naples, Italy; alessio.monteleone@fastwebnet.it
2 Theoreo srl, Via Degli Ulivi 3, 84090 Montecorvino Pugliano, Italy; jtroisi@unisa.it (J.T.); scala@hosmotic.com (G.S.)
4 Mucosal Immunology and Biology Research Center, Massachusetts General Hospital—Harvard Medical School, Boston, MA 02114, USA; gserena@mgh.harvard.edu
5 Department of Eating and Weight Disorders, Villa Garda Hospital, Garda, 37016 Verona, Italy; rdalleg@gmail.com (R.D.G.); si.calugi@gmail.com (S.C.)
3 European Biomedical Research Institute of Salerno (EBRIS), Via S. De Renzi, 3, 84125 Salerno, Italy; afasano@mgh.harvard.edu (A.F.); corrivetti@gmail.com (G.C.)
6 Department of Medicine, Surgery and Dentistry, “Scuola Medica Salernitana”, Neuroscience Section, University of Salerno, 84081 Baronissi, Italy; gcascino@unisa.it (G.C.); francescamarciello81@gmail.com (F.M.)
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/33557302$$D View this record in MEDLINE/PubMed
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Issue 2
Keywords gut microbiome
eating disorders
fecal metabolomics
binge-purging anorexia nervosa
restricting anorexia nervosa
Language English
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Snippet Alterations in the gut microbiome and fecal metabolites have been detected in anorexia nervosa (AN), but differences in those profiles between restricting AN...
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SubjectTerms Adult
Anorexia
Anorexia nervosa
Anorexia Nervosa - microbiology
Anorexia Nervosa - physiopathology
Behavior
binge-purging anorexia nervosa
Comparative analysis
Diagnosis
Diet
Digestive system
Discriminant analysis
Dysbacteriosis
Eating disorders
fecal metabolomics
Feces
Feces - microbiology
Female
Gastrointestinal Microbiome - physiology
gut microbiome
Humans
Intestinal microflora
Laxatives
Lipids
Mental disorders
Metabolism
Metabolites
Metabolomics
Metabolomics - methods
Microbiomes
Microbiota
Microorganisms
Physiology
restricting anorexia nervosa
Secondary analysis
Software
Womens health
Young Adult
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Title The Gut Microbiome and Metabolomics Profiles of Restricting and Binge-Purging Type Anorexia Nervosa
URI https://www.ncbi.nlm.nih.gov/pubmed/33557302
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