Metabolomic basis for response to high dose vitamin D in critical illness

• Published in: Clinical nutrition (Edinburgh, Scotland) Vol. 40; no. 4; pp. 2053 - 2060
• Main Authors: Amrein, Karin, Lasky-Su, Jessica A., Dobnig, Harald, Christopher, Kenneth B.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.2021
• Subjects: Acylcarnitine; Aged; Aged, 80 and over; Cholecalciferol - administration & dosage; clinical nutrition; Critical illness; Critical Illness - mortality; Critical Illness - therapy; dosage; Double-Blind Method; Female; homeostasis; hospitals; Humans; innate immunity; Intensive Care Units; Lysophospholipids - blood; Male; metabolites; Metabolomics; Middle Aged; mitochondria; patients; Phosphatidylethanolamine; phosphatidylethanolamines; Placebos; Plasmalogen; Plasmalogens - blood; sampling; sphingomyelins; Sphingomyelins - blood; Treatment Outcome; Vitamin D; Vitamin D - analogs & derivatives; Vitamin D - blood; Metabolomics; Critical illness; Phosphatidylethanolamine; Vitamin D; VITdAL-ICU trial; FDR; Plasmalogen; OPLS-DA; Acylcarnitine; ITT; CV-ANOVA

It is unclear if intervention can mitigate the dramatic alterations of metabolic homeostasis present in critical illness. Our objective was to determine the associations between increased 25-hydroxyvitamin D levels following high dose vitamin D3 and more favorable metabolomic profiles in critical il...