Real Life Population Pharmacokinetics Modelling of Eight Factors VIII in Patients with Severe Haemophilia A: Is It Always Relevant to Switch to an Extended Half-Life?

• Published in: Pharmaceutics Vol. 12; no. 4; p. 380
• Main Authors: Allard, Quentin, Djerada, Zoubir, Pouplard, Claire, Repessé, Yohann, Desprez, Dominique, Galinat, Hubert, Frotscher, Birgit, Berger, Claire, Harroche, Annie, Ryman, Anne, Flaujac, Claire, Chamouni, Pierre, Guillet, Benoît, Volot, Fabienne, Szymezak, Jean, Nguyen, Philippe, Cazaubon, Yoann
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 21.04.2020; MDPI
• Subjects: Blood groups; Datasets; dose tailoring; factor VIII; Hematology; Hemophilia; Human health and pathology; Life Sciences; modelling; Patients; Pharmaceutical sciences; Pharmacokinetics; Pharmacology; Population; severe haemophilia A; Software; switch; pharmacokinetics; severe haemophilia A; dose tailoring; factor VIII; modelling; switch

We retrospectively analysed the data files of 171 adults and 87 children/adolescents with severe haemophilia, except for 14 patients (moderate; minor) (1), to develop a global population pharmacokinetic (PK) model for eight factors VIII (FVIII) that could estimate individual PK parameters for target...