Therapeutic Potential of Sunitinib in Ameliorating Endothelial Dysfunction in Type 2 Diabetic Rats

• Published in: Pharmacology Vol. 107; no. 3-4; pp. 160 - 166
• Main Authors: Mahdi, Ali, Jiao, Tong, Tratsiakovich, Yahor, Wernly, Bernhard, Yang, Jiangning, Östenson, Claes-Göran, Danser, A.H. Jan, Pernow, John, Zhou, Zhichao
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland 01.03.2022
• Subjects: Animals; Diabetes Mellitus, Experimental - metabolism; Diabetes Mellitus, Type 2 - metabolism; Endothelium, Vascular; Rats; Rats, Wistar; Research Article; Sunitinib - metabolism; Sunitinib - pharmacology; Sunitinib - therapeutic use; Microcirculation; Sunitinib; Endothelial function; Diabetes; Glucose

Abstract Introduction: Sunitinib, a multi-targeted tyrosine kinase receptor inhibitor used to treat renal-cell carcinoma and gastrointestinal stromal tumor, was recently shown to have a beneficial effect on metabolism in type 2 diabetes (T2D). Endothelial dysfunction is a key factor behind macro- an...