Trial-unique, delayed nonmatching-to-location (TUNL): A novel, highly hippocampus-dependent automated touchscreen test of location memory and pattern separation

• Published in: Neurobiology of learning and memory Vol. 94; no. 3; pp. 341 - 352
• Main Authors: Talpos, J.C., McTighe, S.M., Dias, R., Saksida, L.M., Bussey, T.J.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Inc 01.10.2010; Elsevier; Elsevier BV; Academic Press
• Subjects: Analysis of Variance; Animal behavior; Animal memory; Animal models; Animals; Automated; Behavioral psychophysiology; Biological and medical sciences; Delayed nonmatch-to-position; Fundamental and applied biological sciences. Psychology; High-throughput; Hippocampus; Hippocampus - physiology; Male; Memory - physiology; Neurobiology; Pattern Recognition, Visual - physiology; Pattern separation; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Rats; Rodents; Space Perception - physiology; Spatial learning; High-throughput; Automated; Delayed nonmatch-to-position; Pattern separation; Hippocampus; Spatial learning; Central nervous system; Space perception; Encephalon; Touch screen; Acquisition process; Perceptive learning; Spatial memory

► TUNL can be used to study spatial working memory or spatial pattern separation. ► TUNL likely has fewer mediating strategies then other DNMTP tasks. ► TUNL is highly sensitive to the delay-dependent effects of hippocampal lesions. The hippocampus is known to be important for learning and memory, a...