Tracing the temporal-spatial transcriptome landscapes of the human fetal digestive tract using single-cell RNA-sequencing

• Published in: Nature cell biology Vol. 20; no. 6; pp. 721 - 734
• Main Authors: Gao, Shuai, Yan, Liying, Wang, Rui, Li, Jingyun, Yong, Jun, Zhou, Xin, Wei, Yuan, Wu, Xinglong, Wang, Xiaoye, Fan, Xiaoying, Yan, Jie, Zhi, Xu, Gao, Yun, Guo, Hongshan, Jin, Xiao, Wang, Wendong, Mao, Yunuo, Wang, Fengchao, Wen, Lu, Fu, Wei, Ge, Hao, Qiao, Jie, Tang, Fuchou
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.06.2018
• Subjects: Absorption; Adult; Adults; Age Factors; Biological activity; Cell cycle; Cell Differentiation - genetics; Cell Proliferation - genetics; Digestion; Embryos; Epithelial Cells - metabolism; Epithelial Cells - physiology; Esophagus; Fetuses; Gastrointestinal tract; Gastrointestinal Tract - embryology; Gastrointestinal Tract - metabolism; Gastrointestinal Tract - physiology; Gene expression; Gene Expression Profiling - methods; Gene Expression Regulation, Developmental; Gene regulation; Gene sequencing; Genetic Markers; Genotype; Gestation; Gestational Age; Humans; Large intestine; Metabolism; Morphogenesis; Nutrient cycles; Organs; Phenotype; Ribonucleic acid; RNA; Sequence Analysis, RNA - methods; Signal transduction; Single-Cell Analysis - methods; Small intestine; Stomach; Time Factors; Transcriptome

The development of the digestive tract is critical for proper food digestion and nutrient absorption. Here, we analyse the main organs of the digestive tract, including the oesophagus, stomach, small intestine and large intestine, from human embryos between 6 and 25 weeks of gestation as well as the...