Agarwood Oil Nanoemulsion Attenuates Cigarette Smoke-Induced Inflammation and Oxidative Stress Markers in BCi-NS1.1 Airway Epithelial Cells

Chronic obstructive pulmonary disease (COPD) is an irreversible inflammatory respiratory disease characterized by frequent exacerbations and symptoms such as cough and wheezing that lead to irreversible airway damage and hyperresponsiveness. The primary risk factor for COPD is chronic cigarette smok...

Full description

Saved in:
Bibliographic Details
Published inNutrients Vol. 15; no. 4; p. 1019
Main Authors De Rubis, Gabriele, Paudel, Keshav Raj, Manandhar, Bikash, Singh, Sachin Kumar, Gupta, Gaurav, Malik, Raniya, Shen, Jessie, Chami, Aniss, MacLoughlin, Ronan, Chellappan, Dinesh Kumar, Oliver, Brian Gregory George, Hansbro, Philip Michael, Dua, Kamal
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 01.02.2023
MDPI
Subjects
Online AccessGet full text

Cover

Loading…
Abstract Chronic obstructive pulmonary disease (COPD) is an irreversible inflammatory respiratory disease characterized by frequent exacerbations and symptoms such as cough and wheezing that lead to irreversible airway damage and hyperresponsiveness. The primary risk factor for COPD is chronic cigarette smoke exposure, which promotes oxidative stress and a general pro-inflammatory condition by stimulating pro-oxidant and pro-inflammatory pathways and, simultaneously, inactivating anti-inflammatory and antioxidant detoxification pathways. These events cause progressive damage resulting in impaired cell function and disease progression. Treatments available for COPD are generally aimed at reducing the symptoms of exacerbation. Failure to regulate oxidative stress and inflammation results in lung damage. In the quest for innovative treatment strategies, phytochemicals, and complex plant extracts such as agarwood essential oil are promising sources of molecules with antioxidant and anti-inflammatory activity. However, their clinical use is limited by issues such as low solubility and poor pharmacokinetic properties. These can be overcome by encapsulating the therapeutic molecules using advanced drug delivery systems such as polymeric nanosystems and nanoemulsions. In this study, agarwood oil nanoemulsion (agarwood-NE) was formulated and tested for its antioxidant and anti-inflammatory potential in cigarette smoke extract (CSE)-treated BCi-NS1.1 airway basal epithelial cells. The findings suggest successful counteractivity of agarwood-NE against CSE-mediated pro-inflammatory effects by reducing the expression of the pro-inflammatory cytokines IL-1α, IL-1β, IL-8, and GDF-15. In addition, agarwood-NE induced the expression of the anti-inflammatory mediators IL-10, IL-18BP, TFF3, GH, VDBP, relaxin-2, IFN-γ, and PDGF. Furthermore, agarwood-NE also induced the expression of antioxidant genes such as GCLC and GSTP1, simultaneously activating the PI3K pro-survival signalling pathway. This study provides proof of the dual anti-inflammatory and antioxidant activity of agarwood-NE, highlighting its enormous potential for COPD treatment.
AbstractList Chronic obstructive pulmonary disease (COPD) is an irreversible inflammatory respiratory disease characterized by frequent exacerbations and symptoms such as cough and wheezing that lead to irreversible airway damage and hyperresponsiveness. The primary risk factor for COPD is chronic cigarette smoke exposure, which promotes oxidative stress and a general pro-inflammatory condition by stimulating pro-oxidant and pro-inflammatory pathways and, simultaneously, inactivating anti-inflammatory and antioxidant detoxification pathways. These events cause progressive damage resulting in impaired cell function and disease progression. Treatments available for COPD are generally aimed at reducing the symptoms of exacerbation. Failure to regulate oxidative stress and inflammation results in lung damage. In the quest for innovative treatment strategies, phytochemicals, and complex plant extracts such as agarwood essential oil are promising sources of molecules with antioxidant and anti-inflammatory activity. However, their clinical use is limited by issues such as low solubility and poor pharmacokinetic properties. These can be overcome by encapsulating the therapeutic molecules using advanced drug delivery systems such as polymeric nanosystems and nanoemulsions. In this study, agarwood oil nanoemulsion (agarwood-NE) was formulated and tested for its antioxidant and anti-inflammatory potential in cigarette smoke extract (CSE)-treated BCi-NS1.1 airway basal epithelial cells. The findings suggest successful counteractivity of agarwood-NE against CSE-mediated pro-inflammatory effects by reducing the expression of the pro-inflammatory cytokines IL-1α, IL-1β, IL-8, and GDF-15. In addition, agarwood-NE induced the expression of the anti-inflammatory mediators IL-10, IL-18BP, TFF3, GH, VDBP, relaxin-2, IFN-γ, and PDGF. Furthermore, agarwood-NE also induced the expression of antioxidant genes such as GCLC and GSTP1, simultaneously activating the PI3K pro-survival signalling pathway. This study provides proof of the dual anti-inflammatory and antioxidant activity of agarwood-NE, highlighting its enormous potential for COPD treatment.
Audience Academic
Author Malik, Raniya
Shen, Jessie
Oliver, Brian Gregory George
Dua, Kamal
De Rubis, Gabriele
Singh, Sachin Kumar
Manandhar, Bikash
Chellappan, Dinesh Kumar
MacLoughlin, Ronan
Gupta, Gaurav
Hansbro, Philip Michael
Paudel, Keshav Raj
Chami, Aniss
AuthorAffiliation 3 Centre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, School of Life Sciences, Sydney, NSW 2007, Australia
7 Department of Pharmacology, Saveetha Institute of Medical and Technical Sciences, Saveetha Dental College, Saveetha University, Tamil Nadu 602105, Chennai, India
5 School of Pharmacy, Suresh Gyan Vihar University, Jaipur 302017, Rajasthan, India
6 Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun 248007, Uttarakhand, India
13 Department of Life Sciences, School of Pharmacy, International Medical University, Kuala Lumpur 57000, Malaysia
14 Woolcock Institute of Medical Research, University of Sydney, Sydney, NSW 2037, Australia
2 Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, Australia
9 Vitex Pharmaceuticals, Eastern Creek, NSW 2766, Australia
8 DeÁurora Pty Ltd., Dean, VIC 3363, Australia
10 Aerogen, IDA Business
AuthorAffiliation_xml – name: 13 Department of Life Sciences, School of Pharmacy, International Medical University, Kuala Lumpur 57000, Malaysia
– name: 12 School of Pharmacy & Pharmaceutical Sciences, Trinity College, D02 PN40 Dublin, Ireland
– name: 15 School of Life Sciences, University of Technology Sydney, Ultimo, NSW 2007, Australia
– name: 2 Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, Australia
– name: 6 Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun 248007, Uttarakhand, India
– name: 1 Discipline of Pharmacy, Graduate School of Health, University of Technology Sydney, Sydney, NSW 2007, Australia
– name: 5 School of Pharmacy, Suresh Gyan Vihar University, Jaipur 302017, Rajasthan, India
– name: 9 Vitex Pharmaceuticals, Eastern Creek, NSW 2766, Australia
– name: 3 Centre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, School of Life Sciences, Sydney, NSW 2007, Australia
– name: 4 School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-Delhi GT Road, Phagwara 144411, Punjab, India
– name: 11 School of Pharmacy & Biomolecular Sciences, Royal College of Surgeons in Ireland, D02 YN77 Dublin, Ireland
– name: 7 Department of Pharmacology, Saveetha Institute of Medical and Technical Sciences, Saveetha Dental College, Saveetha University, Tamil Nadu 602105, Chennai, India
– name: 14 Woolcock Institute of Medical Research, University of Sydney, Sydney, NSW 2037, Australia
– name: 10 Aerogen, IDA Business Park, H91 HE94 Galway, Ireland
– name: 8 DeÁurora Pty Ltd., Dean, VIC 3363, Australia
Author_xml – sequence: 1
  givenname: Gabriele
  orcidid: 0000-0001-7088-396X
  surname: De Rubis
  fullname: De Rubis, Gabriele
  organization: Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, Australia
– sequence: 2
  givenname: Keshav Raj
  orcidid: 0000-0002-3591-2080
  surname: Paudel
  fullname: Paudel, Keshav Raj
  organization: Centre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, School of Life Sciences, Sydney, NSW 2007, Australia
– sequence: 3
  givenname: Bikash
  orcidid: 0000-0003-1276-6954
  surname: Manandhar
  fullname: Manandhar, Bikash
  organization: Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, Australia
– sequence: 4
  givenname: Sachin Kumar
  orcidid: 0000-0003-3823-6572
  surname: Singh
  fullname: Singh, Sachin Kumar
  organization: School of Pharmaceutical Sciences, Lovely Professional University, Jalandhar-Delhi GT Road, Phagwara 144411, Punjab, India
– sequence: 5
  givenname: Gaurav
  surname: Gupta
  fullname: Gupta, Gaurav
  organization: Department of Pharmacology, Saveetha Institute of Medical and Technical Sciences, Saveetha Dental College, Saveetha University, Tamil Nadu 602105, Chennai, India
– sequence: 6
  givenname: Raniya
  surname: Malik
  fullname: Malik, Raniya
  organization: DeÁurora Pty Ltd., Dean, VIC 3363, Australia
– sequence: 7
  givenname: Jessie
  surname: Shen
  fullname: Shen, Jessie
  organization: DeÁurora Pty Ltd., Dean, VIC 3363, Australia
– sequence: 8
  givenname: Aniss
  surname: Chami
  fullname: Chami, Aniss
  organization: Vitex Pharmaceuticals, Eastern Creek, NSW 2766, Australia
– sequence: 9
  givenname: Ronan
  orcidid: 0000-0002-3164-1607
  surname: MacLoughlin
  fullname: MacLoughlin, Ronan
  organization: School of Pharmacy & Pharmaceutical Sciences, Trinity College, D02 PN40 Dublin, Ireland
– sequence: 10
  givenname: Dinesh Kumar
  orcidid: 0000-0001-5567-6663
  surname: Chellappan
  fullname: Chellappan, Dinesh Kumar
  organization: Department of Life Sciences, School of Pharmacy, International Medical University, Kuala Lumpur 57000, Malaysia
– sequence: 11
  givenname: Brian Gregory George
  orcidid: 0000-0002-7122-9262
  surname: Oliver
  fullname: Oliver, Brian Gregory George
  organization: School of Life Sciences, University of Technology Sydney, Ultimo, NSW 2007, Australia
– sequence: 12
  givenname: Philip Michael
  orcidid: 0000-0002-4741-3035
  surname: Hansbro
  fullname: Hansbro, Philip Michael
  organization: Centre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, School of Life Sciences, Sydney, NSW 2007, Australia
– sequence: 13
  givenname: Kamal
  orcidid: 0000-0002-7507-1159
  surname: Dua
  fullname: Dua, Kamal
  organization: Faculty of Health, Australian Research Centre in Complementary and Integrative Medicine, University of Technology Sydney, Ultimo, NSW 2007, Australia
BackLink https://www.ncbi.nlm.nih.gov/pubmed/36839377$$D View this record in MEDLINE/PubMed
BookMark eNptks1u1DAQgC1URMvSCw-ALHFBSFns2InjC1JYFViptIfC2XLiydbbxN7aSUufgZfGy5a2i7AP_vvms2Y0L9GB8w4Qek3JnDFJPriJFoRTQuUzdJQTkWdlydnBk_0hOo5xTbZDEFGyF-iQlRWTTIgj9Kte6XDrvcHntsdn2nkYpj5a73A9juAmPULEC5soSGd8MfgryJbOTC0YvHRdr4dBj1teuyT5aU063SRwDBAj_qbDFYSIrcOfFjY7u6BzimsbbvUdPtnY8RJ6q3u8gL6Pr9DzTvcRju_XGfrx-eT74mt2ev5luahPs7Zgcsw0kQXjnENeGkmYkLxKiRVVQTppqODANWGMlGVLmKaiEcCoIbIrRE5ZXhg2Q8ud13i9VptgBx3ulNdW_bnwYaV0GG3bgypk0zYdIRUTwPOyqxgTpeFaNzmlDauS6-POtZmaAUwLbgy635Puvzh7qVb-RklZSJF0M_TuXhD89QRxVIONbSqHduCnqHJRkZRLIbbo23_QtZ-CS6VKlEg-QqvqkVrplIB1nU__tlupqgVPBeA0LxM1_w-VpoHBtqnFOpvu9wLe7wLa4GMM0D3kSInadqJ67MQEv3lalQf0b9-x3zMM124
CitedBy_id crossref_primary_10_1016_j_prp_2024_155423
crossref_primary_10_1016_j_fbio_2023_103205
crossref_primary_10_1016_j_lfs_2023_121787
crossref_primary_10_1016_j_prp_2023_154895
crossref_primary_10_1016_j_fbio_2024_103761
crossref_primary_10_1016_j_eurpolymj_2024_113243
crossref_primary_10_1016_j_cyto_2023_156376
crossref_primary_10_1016_j_prp_2024_155295
crossref_primary_10_3390_nu15183985
crossref_primary_10_1007_s10522_023_10050_1
crossref_primary_10_1016_j_lfs_2024_122859
crossref_primary_10_1080_17568919_2024_2347067
crossref_primary_10_1007_s00210_023_02830_w
crossref_primary_10_1016_j_heliyon_2024_e25393
crossref_primary_10_1016_j_prp_2023_154956
crossref_primary_10_1007_s00210_023_02760_7
crossref_primary_10_1016_j_ejmcr_2024_100159
crossref_primary_10_1080_00032719_2024_2325570
Cites_doi 10.3390/antiox11112237
10.1111/jfbc.13572
10.1016/j.phymed.2018.07.006
10.1289/ehp.834959
10.1016/j.tiv.2020.104961
10.1371/journal.pone.0268772
10.1155/2022/2090478
10.23736/S0026-4806.22.07972-1
10.1016/j.cbi.2018.12.009
10.1155/2020/4575030
10.1155/2016/5698931
10.1152/ajplung.00406.2017
10.2217/nnm-2021-0114
10.3390/ijms222011088
10.1016/j.fitote.2016.02.001
10.1016/j.jep.2022.115829
10.1165/rcmb.2013-0348TR
10.3390/nu14183828
10.17305/bjbms.2017.1838
10.3390/molecules18033086
10.3390/molecules27165219
10.1016/j.cdp.2004.07.003
10.1007/s11655-011-0763-6
10.1002/(SICI)1521-4141(199808)28:08<2598::AID-IMMU2598>3.0.CO;2-K
10.2174/1381612826666200610111013
10.2217/nnm-2021-0373
10.1016/j.arbres.2017.02.001
10.18632/aging.202210
10.1164/ajrccm.155.5.9154890
10.1007/s10787-020-00698-3
10.3389/fmed.2020.00554
10.4155/fmc-2021-0097
10.4049/jimmunol.2001182
10.1248/bpb.b18-00805
10.1136/thoraxjnl-2020-216296
10.1111/imr.12616
10.1021/pr100925p
10.1186/1465-9921-11-64
10.1111/jcmm.12802
10.1093/ajhp/zxz306
10.1007/s13205-014-0214-0
10.1016/j.canlet.2003.09.002
10.1111/jfbc.13954
10.1016/j.cca.2015.03.033
10.3390/pharmaceutics14061119
10.1186/s40169-015-0068-z
10.3389/fphar.2020.00047
10.4049/jimmunol.1901330
10.1016/S1074-7613(00)80013-8
10.4155/fmc-2020-0297
10.1111/resp.13032
10.2174/1381612826666200728151610
10.1186/1465-9921-9-80
10.3390/molecules23020342
10.1016/j.jep.2019.112082
10.4155/fmc-2020-0083
10.3390/molecules27196164
10.3390/antiox11050873
10.1513/pats.200411-056SF
10.1016/j.plefa.2014.10.006
10.1080/17476348.2017.1360769
10.1007/s00018-005-5484-6
10.3389/fimmu.2018.02061
10.1097/WOX.0b013e3182439613
10.1016/j.tem.2012.03.006
10.1038/s41419-022-04826-5
10.1165/rcmb.2012-0173OC
10.1002/ddr.21648
10.3389/fmed.2022.983583
10.1155/2016/7432797
10.1080/10717544.2022.2056663
10.1155/2016/9152732
10.1164/rccm.200811-1757ST
10.1016/j.intimp.2019.105792
10.3390/antiox10060921
10.1177/17534666221075493
10.4155/fmc-2019-0338
10.2500/aap.2015.36.3812
10.1186/s12931-022-02167-7
10.2174/1573409911309030012
10.4187/respcare.05912
10.3390/molecules27093038
10.1007/s11356-022-21454-w
10.1183/13993003.01431-2021
10.1183/09031936.00158110
10.3389/fendo.2019.00470
10.4155/fmc-2022-0088
ContentType Journal Article
Copyright COPYRIGHT 2023 MDPI AG
2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
2023 by the authors. 2023
Copyright_xml – notice: COPYRIGHT 2023 MDPI AG
– notice: 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
– notice: 2023 by the authors. 2023
DBID CGR
CUY
CVF
ECM
EIF
NPM
AAYXX
CITATION
3V.
7TS
7X7
7XB
88E
8FI
8FJ
8FK
ABUWG
AFKRA
AZQEC
BENPR
CCPQU
DWQXO
FYUFA
GHDGH
K9.
M0S
M1P
PIMPY
PQEST
PQQKQ
PQUKI
PRINS
7X8
5PM
DOA
DOI 10.3390/nu15041019
DatabaseName Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
CrossRef
ProQuest Central (Corporate)
Physical Education Index
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Medical Database (Alumni Edition)
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Central (Alumni)
ProQuest Central
ProQuest Central Essentials
ProQuest Central
ProQuest One Community College
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Health & Medical Complete (Alumni)
Health & Medical Collection (Alumni Edition)
Medical Database
Publicly Available Content (ProQuest)
ProQuest One Academic Eastern Edition (DO NOT USE)
ProQuest One Academic
ProQuest One Academic UKI Edition
ProQuest Central China
MEDLINE - Academic
PubMed Central (Full Participant titles)
DOAJ Directory of Open Access Journals
DatabaseTitle MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
CrossRef
Publicly Available Content Database
ProQuest Central Essentials
ProQuest One Academic Eastern Edition
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
ProQuest Central China
ProQuest Hospital Collection (Alumni)
Physical Education Index
ProQuest Central
ProQuest Health & Medical Complete
Health Research Premium Collection
ProQuest Medical Library
ProQuest One Academic UKI Edition
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
ProQuest One Academic
ProQuest Medical Library (Alumni)
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic


CrossRef
MEDLINE

Publicly Available Content Database
Database_xml – sequence: 1
  dbid: DOA
  name: Directory of Open Access Journals
  url: https://www.doaj.org/
  sourceTypes: Open Website
– sequence: 2
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 3
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
– sequence: 4
  dbid: 7X7
  name: Health & Medical Collection
  url: https://search.proquest.com/healthcomplete
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Anatomy & Physiology
EISSN 2072-6643
ExternalDocumentID oai_doaj_org_article_59bcbf00837e426f83376d4aab211b38
A743254126
10_3390_nu15041019
36839377
Genre Journal Article
GeographicLocations Australia
GeographicLocations_xml – name: Australia
GrantInformation_xml – fundername: University of Technology Sydney
GroupedDBID ---
3V.
53G
5VS
7X7
88E
8FE
8FH
8FI
8FJ
A8Z
AADQD
AAFWJ
AAHBH
AAWTL
ABUWG
ACIWK
ACPRK
AENEX
AFKRA
AFRAH
AFZYC
ALIPV
ALMA_UNASSIGNED_HOLDINGS
APEBS
ATCPS
BBNVY
BENPR
BHPHI
BPHCQ
BVXVI
CCPQU
CGR
CUY
CVF
DIK
E3Z
EBD
ECGQY
ECM
EIF
EIHBH
ESTFP
EYRJQ
F5P
FYUFA
GROUPED_DOAJ
GX1
HCIFZ
HMCUK
HYE
IAO
ITC
KQ8
LK8
M0K
M1P
M48
M7P
MODMG
M~E
NPM
OK1
OZF
P2P
P6G
PGMZT
PIMPY
PQQKQ
PROAC
PSQYO
RIG
RNS
RPM
TR2
UKHRP
AAYXX
CITATION
7TS
7XB
8FK
AZQEC
DWQXO
K9.
PQEST
PQUKI
PRINS
7X8
5PM
AFPKN
ID FETCH-LOGICAL-c539t-a0953444e26d90379480705850f9d174e4a033066c03a17b7e31d09f5721325d3
IEDL.DBID RPM
ISSN 2072-6643
IngestDate Mon Oct 07 19:33:41 EDT 2024
Tue Sep 17 21:32:07 EDT 2024
Wed Dec 04 04:34:50 EST 2024
Thu Oct 31 21:40:07 EDT 2024
Tue Nov 19 21:44:04 EST 2024
Tue Nov 12 23:53:56 EST 2024
Fri Dec 06 07:25:38 EST 2024
Sat Nov 02 12:24:22 EDT 2024
IsDoiOpenAccess true
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 4
Keywords phytoceuticals
inflammation
nutraceuticals
drug delivery
agarwood
cigarette smoke
nanoemulsion
chronic obstructive pulmonary disease
Language English
License https://creativecommons.org/licenses/by/4.0
Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c539t-a0953444e26d90379480705850f9d174e4a033066c03a17b7e31d09f5721325d3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
These two authors have contributed equally.
ORCID 0000-0003-1276-6954
0000-0003-3823-6572
0000-0002-3164-1607
0000-0001-5567-6663
0000-0002-7122-9262
0000-0002-3591-2080
0000-0001-7088-396X
0000-0002-4741-3035
0000-0002-7507-1159
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9959783/
PMID 36839377
PQID 2779590188
PQPubID 2032353
ParticipantIDs doaj_primary_oai_doaj_org_article_59bcbf00837e426f83376d4aab211b38
pubmedcentral_primary_oai_pubmedcentral_nih_gov_9959783
proquest_miscellaneous_2780066573
proquest_journals_2779590188
gale_infotracmisc_A743254126
gale_infotracacademiconefile_A743254126
crossref_primary_10_3390_nu15041019
pubmed_primary_36839377
PublicationCentury 2000
PublicationDate 2023-02-01
PublicationDateYYYYMMDD 2023-02-01
PublicationDate_xml – month: 02
  year: 2023
  text: 2023-02-01
  day: 01
PublicationDecade 2020
PublicationPlace Switzerland
PublicationPlace_xml – name: Switzerland
– name: Basel
PublicationTitle Nutrients
PublicationTitleAlternate Nutrients
PublicationYear 2023
Publisher MDPI AG
MDPI
Publisher_xml – name: MDPI AG
– name: MDPI
References ref_94
Chitre (ref_56) 2007; 1
Mehta (ref_8) 2021; 13
Chellappan (ref_77) 2021; 13
Kratzer (ref_19) 2013; 48
ref_12
Hardwick (ref_44) 2021; 27
Lugg (ref_6) 2022; 77
ref_10
ref_53
Jaiswal (ref_67) 2015; 5
ref_52
Wang (ref_58) 2019; 42
Tweed (ref_21) 2012; 23
Mueller (ref_17) 2015; 445
Birben (ref_37) 2012; 5
Liu (ref_51) 2013; 18
Paudel (ref_65) 2022; 14
Vogelmeier (ref_3) 2017; 53
Nyunoya (ref_86) 2014; 50
Lee (ref_93) 2018; 9
Liu (ref_2) 2022; 60
Duffney (ref_31) 2018; 314
Pini (ref_26) 2016; 20
Modestou (ref_32) 2010; 11
Hamouda (ref_60) 2019; 8
Bollmeier (ref_4) 2020; 77
ref_69
Mehta (ref_5) 2020; 28
Peng (ref_54) 2020; 2020
Bortner (ref_23) 2011; 10
ref_66
Ma (ref_89) 2015; 94
Dupuis (ref_68) 2022; 29
Eapen (ref_1) 2017; 11
Lee (ref_50) 2015; 2015
Yadav (ref_55) 2013; 9
Hu (ref_16) 2022; 2022
Paudel (ref_45) 2020; 68
Ng (ref_62) 2020; 26
MacNee (ref_83) 2005; 2
Watson (ref_78) 2022; 16
Leung (ref_33) 2017; 22
Mao (ref_38) 2004; 28
Ketterer (ref_36) 1983; 49
Rezaei (ref_88) 2022; Volume 3
Feng (ref_91) 2022; 23
Panth (ref_35) 2016; 2016
Chellappan (ref_72) 2020; 81
Solanki (ref_46) 2020; 12
King (ref_71) 2015; 4
Biswas (ref_76) 2016; 2016
Putcha (ref_40) 2018; 63
Kim (ref_47) 2022; 13
Kim (ref_49) 2020; 253
Kew (ref_22) 2019; 10
Hurme (ref_92) 1998; 28
Wang (ref_59) 2021; 2021
ref_79
Pauwels (ref_90) 2011; 38
Allam (ref_41) 2022; 29
Kuo (ref_42) 2004; 203
Mio (ref_13) 1997; 155
Mehta (ref_43) 2021; 45
May (ref_74) 2015; 36
Dua (ref_7) 2019; 299
Eisner (ref_75) 2010; 182
Wang (ref_25) 2019; 75
Malyla (ref_9) 2020; 12
Zhao (ref_81) 2022; 301
Li (ref_30) 2020; 12
ref_82
ref_80
Nieto (ref_20) 2020; 205
Harju (ref_39) 2008; 9
Li (ref_29) 2013; 19
Kardas (ref_24) 2020; 11
Paudel (ref_73) 2020; 7
Liu (ref_61) 2016; 109
ref_87
Belovari (ref_28) 2017; 17
Paudel (ref_64) 2022; 9
ref_84
Novick (ref_18) 1999; 10
Kaplanski (ref_14) 2018; 281
Nucera (ref_34) 2022; 113
Chan (ref_63) 2021; 16
Wadhwa (ref_70) 2021; 45
ref_48
Thim (ref_27) 2005; 62
Jiang (ref_15) 2018; 16
Zheng (ref_57) 2019; 54
Hussain (ref_85) 2016; 2016
Milad (ref_11) 2021; 206
References_xml – ident: ref_10
  doi: 10.3390/antiox11112237
– volume: 45
  start-page: e13572
  year: 2021
  ident: ref_70
  article-title: Anti-inflammatory and anticancer activities of Naringenin-loaded liquid crystalline nanoparticles in vitro
  publication-title: J. Food Biochem.
  doi: 10.1111/jfbc.13572
  contributor:
    fullname: Wadhwa
– volume: 54
  start-page: 308
  year: 2019
  ident: ref_57
  article-title: The protective effects of Aquilariae Lignum Resinatum extract on 5-Fuorouracil-induced intestinal mucositis in mice
  publication-title: Phytomedicine
  doi: 10.1016/j.phymed.2018.07.006
  contributor:
    fullname: Zheng
– volume: 49
  start-page: 59
  year: 1983
  ident: ref_36
  article-title: The role of glutathione in detoxication
  publication-title: Environ. Health Perspect.
  doi: 10.1289/ehp.834959
  contributor:
    fullname: Ketterer
– volume: 68
  start-page: 104961
  year: 2020
  ident: ref_45
  article-title: Rutin loaded liquid crystalline nanoparticles inhibit lipopolysaccharide induced oxidative stress and apoptosis in bronchial epithelial cells in vitro
  publication-title: Toxicol. In Vitro
  doi: 10.1016/j.tiv.2020.104961
  contributor:
    fullname: Paudel
– ident: ref_79
  doi: 10.1371/journal.pone.0268772
– volume: 2022
  start-page: 2090478
  year: 2022
  ident: ref_16
  article-title: Peitu Shengjin Recipe Attenuates Airway Inflammation via the TLR4/NF-kB Signaling Pathway on Chronic Obstructive Pulmonary Disease
  publication-title: Evid. Based Complement. Alternat. Med.
  doi: 10.1155/2022/2090478
  contributor:
    fullname: Hu
– volume: 113
  start-page: 370
  year: 2022
  ident: ref_34
  article-title: Role of oxidative stress in the pathogenesis of COPD
  publication-title: Minerva Med.
  doi: 10.23736/S0026-4806.22.07972-1
  contributor:
    fullname: Nucera
– volume: 299
  start-page: 168
  year: 2019
  ident: ref_7
  article-title: Increasing complexity and interactions of oxidative stress in chronic respiratory diseases: An emerging need for novel drug delivery systems
  publication-title: Chemico.-Biological. Interactions
  doi: 10.1016/j.cbi.2018.12.009
  contributor:
    fullname: Dua
– volume: 2020
  start-page: 4575030
  year: 2020
  ident: ref_54
  article-title: Chemical Constituents and Anti-Inflammatory Effect of Incense Smoke from Agarwood Determined by GC-MS
  publication-title: Int. J. Anal. Chem.
  doi: 10.1155/2020/4575030
  contributor:
    fullname: Peng
– volume: 2016
  start-page: 5698931
  year: 2016
  ident: ref_76
  article-title: Does the Interdependence between Oxidative Stress and Inflammation Explain the Antioxidant Paradox?
  publication-title: Oxid. Med. Cell Longev.
  doi: 10.1155/2016/5698931
  contributor:
    fullname: Biswas
– ident: ref_84
– volume: 314
  start-page: L505
  year: 2018
  ident: ref_31
  article-title: Cigarette smoke dampens antiviral signaling in small airway epithelial cells by disrupting TLR3 cleavage
  publication-title: Am. J. Physiol. Lung Cell Mol. Physiol.
  doi: 10.1152/ajplung.00406.2017
  contributor:
    fullname: Duffney
– volume: 16
  start-page: 1545
  year: 2021
  ident: ref_63
  article-title: Versatility of liquid crystalline nanoparticles in inflammatory lung diseases
  publication-title: Nanomedicine
  doi: 10.2217/nnm-2021-0114
  contributor:
    fullname: Chan
– ident: ref_94
  doi: 10.3390/ijms222011088
– volume: 109
  start-page: 274
  year: 2016
  ident: ref_61
  article-title: Research progress on berberine with a special focus on its oral bioavailability
  publication-title: Fitoterapia
  doi: 10.1016/j.fitote.2016.02.001
  contributor:
    fullname: Liu
– volume: 301
  start-page: 115829
  year: 2022
  ident: ref_81
  article-title: Molecular mechanism of the anti-inflammatory effects of plant essential oils: A systematic review
  publication-title: J. Ethnopharmacol.
  doi: 10.1016/j.jep.2022.115829
  contributor:
    fullname: Zhao
– volume: 50
  start-page: 471
  year: 2014
  ident: ref_86
  article-title: Molecular processes that drive cigarette smoke-induced epithelial cell fate of the lung
  publication-title: Am. J. Respir. Cell Mol. Biol.
  doi: 10.1165/rcmb.2013-0348TR
  contributor:
    fullname: Nyunoya
– ident: ref_66
  doi: 10.3390/nu14183828
– volume: 17
  start-page: 241
  year: 2017
  ident: ref_28
  article-title: Localization of trefoil factor family peptide 3 (TFF3) in epithelial tissues originating from the three germ layers of developing mouse embryo
  publication-title: Bosn. J. Basic Med. Sci.
  doi: 10.17305/bjbms.2017.1838
  contributor:
    fullname: Belovari
– volume: 18
  start-page: 3086
  year: 2013
  ident: ref_51
  article-title: Whole-tree agarwood-inducing technique: An efficient novel technique for producing high-quality agarwood in cultivated Aquilaria sinensis trees
  publication-title: Molecules
  doi: 10.3390/molecules18033086
  contributor:
    fullname: Liu
– ident: ref_80
  doi: 10.3390/molecules27165219
– volume: 16
  start-page: 12
  year: 2018
  ident: ref_15
  article-title: IL-17A and GDF15 are able to induce epithelial-mesenchymal transition of lung epithelial cells in response to cigarette smoke
  publication-title: Exp. Ther. Med.
  contributor:
    fullname: Jiang
– volume: 28
  start-page: 368
  year: 2004
  ident: ref_38
  article-title: Glutathione S-transferase P1 Ile105Val polymorphism, cigarette smoking and prostate cancer
  publication-title: Cancer Detect. Prev.
  doi: 10.1016/j.cdp.2004.07.003
  contributor:
    fullname: Mao
– volume: 19
  start-page: 29
  year: 2013
  ident: ref_29
  article-title: Synergistic anti-inflammatory effect of Radix Platycodon in combination with herbs for cleaning-heat and detoxification and its mechanism
  publication-title: Chin. J. Integr. Med.
  doi: 10.1007/s11655-011-0763-6
  contributor:
    fullname: Li
– volume: 28
  start-page: 2598
  year: 1998
  ident: ref_92
  article-title: IL-1 receptor antagonist (IL-1Ra) plasma levels are co-ordinately regulated by both IL-1Ra and IL-1beta genes
  publication-title: Eur. J. Immunol.
  doi: 10.1002/(SICI)1521-4141(199808)28:08<2598::AID-IMMU2598>3.0.CO;2-K
  contributor:
    fullname: Hurme
– volume: 26
  start-page: 4580
  year: 2020
  ident: ref_62
  article-title: Applications of Nanocarriers as Drug Delivery Vehicles for Active Phytoconstituents
  publication-title: Curr. Pharm. Des.
  doi: 10.2174/1381612826666200610111013
  contributor:
    fullname: Ng
– ident: ref_87
  doi: 10.2217/nnm-2021-0373
– volume: 53
  start-page: 128
  year: 2017
  ident: ref_3
  article-title: Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Lung Disease 2017 Report: GOLD Executive Summary
  publication-title: Arch. Bronconeumol.
  doi: 10.1016/j.arbres.2017.02.001
  contributor:
    fullname: Vogelmeier
– volume: 12
  start-page: 24301
  year: 2020
  ident: ref_30
  article-title: Cigarette smoke extract induces airway epithelial cell death via repressing PRMT6/AKT signaling
  publication-title: Aging
  doi: 10.18632/aging.202210
  contributor:
    fullname: Li
– volume: 155
  start-page: 1770
  year: 1997
  ident: ref_13
  article-title: Cigarette smoke induces interleukin-8 release from human bronchial epithelial cells
  publication-title: Am. J. Respir. Crit. Care. Med.
  doi: 10.1164/ajrccm.155.5.9154890
  contributor:
    fullname: Mio
– volume: 28
  start-page: 795
  year: 2020
  ident: ref_5
  article-title: Cellular signalling pathways mediating the pathogenesis of chronic inflammatory respiratory diseases: An update
  publication-title: Inflammopharmacology
  doi: 10.1007/s10787-020-00698-3
  contributor:
    fullname: Mehta
– volume: 7
  start-page: 554
  year: 2020
  ident: ref_73
  article-title: Role of Lung Microbiome in Innate Immune Response Associated With Chronic Lung Diseases
  publication-title: Front. Med.
  doi: 10.3389/fmed.2020.00554
  contributor:
    fullname: Paudel
– volume: 13
  start-page: 1249
  year: 2021
  ident: ref_77
  article-title: Mitochondrial dysfunctions associated with chronic respiratory diseases and their targeted therapies: An update
  publication-title: Future Med. Chem.
  doi: 10.4155/fmc-2021-0097
  contributor:
    fullname: Chellappan
– volume: 206
  start-page: 1923
  year: 2021
  ident: ref_11
  article-title: Neutrophils and IL-1α Regulate Surfactant Homeostasis during Cigarette Smoking
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.2001182
  contributor:
    fullname: Milad
– volume: 42
  start-page: 1112
  year: 2019
  ident: ref_58
  article-title: Agarwood Extract Mitigates Intestinal Injury in Fluorouracil-Induced Mice
  publication-title: Biol. Pharm. Bull.
  doi: 10.1248/bpb.b18-00805
  contributor:
    fullname: Wang
– volume: 77
  start-page: 94
  year: 2022
  ident: ref_6
  article-title: Cigarette smoke exposure and alveolar macrophages: Mechanisms for lung disease
  publication-title: Thorax
  doi: 10.1136/thoraxjnl-2020-216296
  contributor:
    fullname: Lugg
– volume: 1
  start-page: 288
  year: 2007
  ident: ref_56
  article-title: Analgesic and anti-inflammatory activity of heartwood of Aquilaria agallocha in laboratory animals
  publication-title: Pharmacol. Online
  contributor:
    fullname: Chitre
– volume: 8
  start-page: 1
  year: 2019
  ident: ref_60
  article-title: A biochemical study of agarwood on methanol injection in rat
  publication-title: J. Drug Alcohol Res.
  contributor:
    fullname: Hamouda
– volume: 281
  start-page: 138
  year: 2018
  ident: ref_14
  article-title: Interleukin-18: Biological properties and role in disease pathogenesis
  publication-title: Immunol. Rev.
  doi: 10.1111/imr.12616
  contributor:
    fullname: Kaplanski
– volume: 10
  start-page: 1151
  year: 2011
  ident: ref_23
  article-title: Proteomic profiling of human plasma by iTRAQ reveals down-regulation of ITI-HC3 and VDBP by cigarette smoking
  publication-title: J. Proteome. Res.
  doi: 10.1021/pr100925p
  contributor:
    fullname: Bortner
– volume: 11
  start-page: 64
  year: 2010
  ident: ref_32
  article-title: Inhibition of IFN-gamma-dependent antiviral airway epithelial defense by cigarette smoke
  publication-title: Respir. Res.
  doi: 10.1186/1465-9921-11-64
  contributor:
    fullname: Modestou
– volume: 20
  start-page: 891
  year: 2016
  ident: ref_26
  article-title: Protection from cigarette smoke-induced vascular injury by recombinant human relaxin-2 (serelaxin)
  publication-title: J. Cell Mol. Med.
  doi: 10.1111/jcmm.12802
  contributor:
    fullname: Pini
– volume: 77
  start-page: 259
  year: 2020
  ident: ref_4
  article-title: Management of chronic obstructive pulmonary disease: A review focusing on exacerbations
  publication-title: Am. J. Health Syst. Pharm.
  doi: 10.1093/ajhp/zxz306
  contributor:
    fullname: Bollmeier
– volume: 5
  start-page: 123
  year: 2015
  ident: ref_67
  article-title: Nanoemulsion: An advanced mode of drug delivery system
  publication-title: 3 Biotech
  doi: 10.1007/s13205-014-0214-0
  contributor:
    fullname: Jaiswal
– volume: 203
  start-page: 127
  year: 2004
  ident: ref_42
  article-title: The anti-inflammatory potential of berberine in vitro and in vivo
  publication-title: Cancer Lett.
  doi: 10.1016/j.canlet.2003.09.002
  contributor:
    fullname: Kuo
– volume: 45
  start-page: e13954
  year: 2021
  ident: ref_43
  article-title: Berberine loaded liquid crystalline nanostructure inhibits cancer progression in adenocarcinomic human alveolar basal epithelial cells in vitro
  publication-title: J. Food Biochem.
  doi: 10.1111/jfbc.13954
  contributor:
    fullname: Mehta
– volume: 445
  start-page: 155
  year: 2015
  ident: ref_17
  article-title: Association of the biomarkers soluble ST2, galectin-3 and growth-differentiation factor-15 with heart failure and other non-cardiac diseases
  publication-title: Clin. Chim. Acta
  doi: 10.1016/j.cca.2015.03.033
  contributor:
    fullname: Mueller
– ident: ref_69
  doi: 10.3390/pharmaceutics14061119
– volume: 4
  start-page: 68
  year: 2015
  ident: ref_71
  article-title: Inflammation in chronic obstructive pulmonary disease and its role in cardiovascular disease and lung cancer
  publication-title: Clin. Transl. Med.
  doi: 10.1186/s40169-015-0068-z
  contributor:
    fullname: King
– volume: 11
  start-page: 47
  year: 2020
  ident: ref_24
  article-title: Role of Platelet-Derived Growth Factor (PDGF) in Asthma as an Immunoregulatory Factor Mediating Airway Remodeling and Possible Pharmacological Target
  publication-title: Front. Pharmacol.
  doi: 10.3389/fphar.2020.00047
  contributor:
    fullname: Kardas
– volume: 205
  start-page: 776
  year: 2020
  ident: ref_20
  article-title: Growth Hormone Reprograms Macrophages toward an Anti-Inflammatory and Reparative Profile in an MAFB-Dependent Manner
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1901330
  contributor:
    fullname: Nieto
– volume: 10
  start-page: 127
  year: 1999
  ident: ref_18
  article-title: Interleukin-18 binding protein: A novel modulator of the Th1 cytokine response
  publication-title: Immunity
  doi: 10.1016/S1074-7613(00)80013-8
  contributor:
    fullname: Novick
– volume: 13
  start-page: 543
  year: 2021
  ident: ref_8
  article-title: Rutin-loaded liquid crystalline nanoparticles attenuate oxidative stress in bronchial epithelial cells: A PCR validation
  publication-title: Future Med. Chem.
  doi: 10.4155/fmc-2020-0297
  contributor:
    fullname: Mehta
– volume: 22
  start-page: 634
  year: 2017
  ident: ref_33
  article-title: The role of acute and chronic respiratory colonization and infections in the pathogenesis of COPD
  publication-title: Respirology
  doi: 10.1111/resp.13032
  contributor:
    fullname: Leung
– volume: 27
  start-page: 2
  year: 2021
  ident: ref_44
  article-title: Targeting Cancer using Curcumin Encapsulated Vesicular Drug Delivery Systems
  publication-title: Curr. Pharm. Des.
  doi: 10.2174/1381612826666200728151610
  contributor:
    fullname: Hardwick
– volume: 9
  start-page: 80
  year: 2008
  ident: ref_39
  article-title: Glutathione-S-transferases in lung and sputum specimens, effects of smoking and COPD severity
  publication-title: Respir. Res.
  doi: 10.1186/1465-9921-9-80
  contributor:
    fullname: Harju
– ident: ref_52
  doi: 10.3390/molecules23020342
– volume: 253
  start-page: 112082
  year: 2020
  ident: ref_49
  article-title: Eriobotrya japonica leaf extract attenuates airway inflammation in ovalbumin-induced mice model of asthma
  publication-title: J. Ethnopharmacol.
  doi: 10.1016/j.jep.2019.112082
  contributor:
    fullname: Kim
– volume: 12
  start-page: 2019
  year: 2020
  ident: ref_46
  article-title: Antiproliferative effects of boswellic acid-loaded chitosan nanoparticles on human lung cancer cell line A549
  publication-title: Future Med. Chem.
  doi: 10.4155/fmc-2020-0083
  contributor:
    fullname: Solanki
– ident: ref_82
  doi: 10.3390/molecules27196164
– ident: ref_12
  doi: 10.3390/antiox11050873
– volume: 2
  start-page: 50
  year: 2005
  ident: ref_83
  article-title: Pulmonary and systemic oxidant/antioxidant imbalance in chronic obstructive pulmonary disease
  publication-title: Proc. Am. Thorac. Soc.
  doi: 10.1513/pats.200411-056SF
  contributor:
    fullname: MacNee
– volume: 94
  start-page: 13
  year: 2015
  ident: ref_89
  article-title: Epoxyeicosatrienoic acids attenuate cigarette smoke extract-induced interleukin-8 production in bronchial epithelial cells
  publication-title: Prostaglandins Leukot. Essent. Fatty Acids
  doi: 10.1016/j.plefa.2014.10.006
  contributor:
    fullname: Ma
– volume: 11
  start-page: 827
  year: 2017
  ident: ref_1
  article-title: Airway inflammation in chronic obstructive pulmonary disease (COPD): A true paradox
  publication-title: Expert Rev. Respir. Med.
  doi: 10.1080/17476348.2017.1360769
  contributor:
    fullname: Eapen
– volume: 62
  start-page: 2956
  year: 2005
  ident: ref_27
  article-title: Structure of mammalian trefoil factors and functional insights
  publication-title: Cell Mol. Life Sci.
  doi: 10.1007/s00018-005-5484-6
  contributor:
    fullname: Thim
– volume: Volume 3
  start-page: 311
  year: 2022
  ident: ref_88
  article-title: Chapter 14—Role of autoimmunity in the pathogenesis of chronic obstructive pulmonary disease and pulmonary emphysema
  publication-title: Translational Autoimmunity
  contributor:
    fullname: Rezaei
– volume: 9
  start-page: 2061
  year: 2018
  ident: ref_93
  article-title: The Dual Nature of Type I and Type II Interferons
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2018.02061
  contributor:
    fullname: Lee
– volume: 5
  start-page: 9
  year: 2012
  ident: ref_37
  article-title: Oxidative stress and antioxidant defense
  publication-title: World Allergy Organ. J.
  doi: 10.1097/WOX.0b013e3182439613
  contributor:
    fullname: Birben
– volume: 23
  start-page: 334
  year: 2012
  ident: ref_21
  article-title: The endocrine effects of nicotine and cigarette smoke
  publication-title: Trends Endocrinol. Metab.
  doi: 10.1016/j.tem.2012.03.006
  contributor:
    fullname: Tweed
– volume: 13
  start-page: 374
  year: 2022
  ident: ref_47
  article-title: ROR activation by Nobiletin enhances antitumor efficacy via suppression of IkappaB/NF-kappaB signaling in triple-negative breast cancer
  publication-title: Cell Death Dis.
  doi: 10.1038/s41419-022-04826-5
  contributor:
    fullname: Kim
– volume: 2021
  start-page: 9944685
  year: 2021
  ident: ref_59
  article-title: Agarwood Alcohol Extract Protects against Gastric Ulcer by Inhibiting Oxidation and Inflammation
  publication-title: Evid. Based. Complement. Alternat. Med.
  contributor:
    fullname: Wang
– volume: 48
  start-page: 725
  year: 2013
  ident: ref_19
  article-title: Role of IL-18 in second-hand smoke-induced emphysema
  publication-title: Am. J. Respir. Cell Mol. Biol.
  doi: 10.1165/rcmb.2012-0173OC
  contributor:
    fullname: Kratzer
– volume: 81
  start-page: 419
  year: 2020
  ident: ref_72
  article-title: Targeting neutrophils using novel drug delivery systems in chronic respiratory diseases
  publication-title: Drug Dev. Res.
  doi: 10.1002/ddr.21648
  contributor:
    fullname: Chellappan
– volume: 9
  start-page: 983583
  year: 2022
  ident: ref_64
  article-title: Editorial: Advanced therapeutic delivery for the management of chronic respiratory diseases
  publication-title: Front. Med.
  doi: 10.3389/fmed.2022.983583
  contributor:
    fullname: Paudel
– volume: 2016
  start-page: 7432797
  year: 2016
  ident: ref_85
  article-title: Oxidative Stress and Inflammation: What Polyphenols Can Do for Us?
  publication-title: Oxid. Med. Cell Longev.
  doi: 10.1155/2016/7432797
  contributor:
    fullname: Hussain
– volume: 29
  start-page: 1007
  year: 2022
  ident: ref_68
  article-title: Nanodelivery of essential oils as efficient tools against antimicrobial resistance: A review of the type and physical-chemical properties of the delivery systems and applications
  publication-title: Drug Deliv.
  doi: 10.1080/10717544.2022.2056663
  contributor:
    fullname: Dupuis
– volume: 2016
  start-page: 9152732
  year: 2016
  ident: ref_35
  article-title: Reactive Oxygen Species: A Key Hallmark of Cardiovascular Disease
  publication-title: Adv. Med.
  doi: 10.1155/2016/9152732
  contributor:
    fullname: Panth
– volume: 182
  start-page: 693
  year: 2010
  ident: ref_75
  article-title: An official American Thoracic Society public policy statement: Novel risk factors and the global burden of chronic obstructive pulmonary disease
  publication-title: Am. J. Respir. Crit. Care. Med.
  doi: 10.1164/rccm.200811-1757ST
  contributor:
    fullname: Eisner
– volume: 75
  start-page: 105792
  year: 2019
  ident: ref_25
  article-title: Platelet-derived growth factor B attenuates lethal sepsis through inhibition of inflammatory responses
  publication-title: Int. Immunopharmacol.
  doi: 10.1016/j.intimp.2019.105792
  contributor:
    fullname: Wang
– ident: ref_48
  doi: 10.3390/antiox10060921
– volume: 16
  start-page: 17534666221075493
  year: 2022
  ident: ref_78
  article-title: Digital healthcare in COPD management: A narrative review on the advantages, pitfalls, and need for further research
  publication-title: Ther. Adv. Respir. Dis.
  doi: 10.1177/17534666221075493
  contributor:
    fullname: Watson
– volume: 12
  start-page: 567
  year: 2020
  ident: ref_9
  article-title: Recent advances in experimental animal models of lung cancer
  publication-title: Future Med. Chem.
  doi: 10.4155/fmc-2019-0338
  contributor:
    fullname: Malyla
– volume: 2015
  start-page: 502182
  year: 2015
  ident: ref_50
  article-title: Terminalia chebula Fructus Inhibits Migration and Proliferation of Vascular Smooth Muscle Cells and Production of Inflammatory Mediators in RAW 264.7
  publication-title: Evid. Based Complement. Alternat. Med.
  contributor:
    fullname: Lee
– volume: 36
  start-page: 4
  year: 2015
  ident: ref_74
  article-title: Burden of chronic obstructive pulmonary disease: Healthcare costs and beyond
  publication-title: Allergy Asthma Proc.
  doi: 10.2500/aap.2015.36.3812
  contributor:
    fullname: May
– volume: 23
  start-page: 244
  year: 2022
  ident: ref_91
  article-title: IL-37 protects against airway remodeling by reversing bronchial epithelial-mesenchymal transition via IL-24 signaling pathway in chronic asthma
  publication-title: Respir. Res.
  doi: 10.1186/s12931-022-02167-7
  contributor:
    fullname: Feng
– volume: 9
  start-page: 360
  year: 2013
  ident: ref_55
  article-title: Molecular docking and ADME studies of natural compounds of Agarwood oil for topical anti-inflammatory activity
  publication-title: Curr. Comput. Aided Drug Des.
  doi: 10.2174/1573409911309030012
  contributor:
    fullname: Yadav
– volume: 63
  start-page: 773
  year: 2018
  ident: ref_40
  article-title: Medication Regimens for Managing COPD Exacerbations
  publication-title: Respir Care
  doi: 10.4187/respcare.05912
  contributor:
    fullname: Putcha
– ident: ref_53
  doi: 10.3390/molecules27093038
– volume: 29
  start-page: 62733
  year: 2022
  ident: ref_41
  article-title: Nutraceuticals and mitochondrial oxidative stress: Bridging the gap in the management of bronchial asthma
  publication-title: Environ. Sci. Pollut. Res. Int.
  doi: 10.1007/s11356-022-21454-w
  contributor:
    fullname: Allam
– volume: 60
  start-page: 2101431
  year: 2022
  ident: ref_2
  article-title: Adverse roles of mast cell chymase-1 in chronic obstructive pulmonary disease
  publication-title: Eur. Respir. J.
  doi: 10.1183/13993003.01431-2021
  contributor:
    fullname: Liu
– volume: 38
  start-page: 1019
  year: 2011
  ident: ref_90
  article-title: Role of IL-1α and the Nlrp3/caspase-1/IL-1β axis in cigarette smoke-induced pulmonary inflammation and COPD
  publication-title: Eur. Respir. J.
  doi: 10.1183/09031936.00158110
  contributor:
    fullname: Pauwels
– volume: 10
  start-page: 470
  year: 2019
  ident: ref_22
  article-title: The Vitamin D Binding Protein and Inflammatory Injury: A Mediator or Sentinel of Tissue Damage?
  publication-title: Front. Endocrinol.
  doi: 10.3389/fendo.2019.00470
  contributor:
    fullname: Kew
– volume: 14
  start-page: 1293
  year: 2022
  ident: ref_65
  article-title: Advances in research with rutin-loaded nanoformulations in mitigating lung diseases
  publication-title: Future Med. Chem.
  doi: 10.4155/fmc-2022-0088
  contributor:
    fullname: Paudel
SSID ssj0000070763
Score 2.4906423
Snippet Chronic obstructive pulmonary disease (COPD) is an irreversible inflammatory respiratory disease characterized by frequent exacerbations and symptoms such as...
SourceID doaj
pubmedcentral
proquest
gale
crossref
pubmed
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
StartPage 1019
SubjectTerms 1-Phosphatidylinositol 3-kinase
agarwood
Anti-Inflammatory Agents - pharmacology
Antioxidants
Antioxidants - pharmacology
Care and treatment
Chemical properties
Chronic obstructive pulmonary disease
Cigarette smoke
Cigarette Smoking
Cigarettes
Cough
Cytokines
Detoxification
Development and progression
Dilleniidae
Drug delivery
Drug delivery systems
Enzymes
Epithelial Cells
Epithelium
Essences and essential oils
Essential oils
Gene expression
Glutathione transferase
Health aspects
Health services
Inflammation
Inflammation - metabolism
Inflammatory diseases
Interleukin 10
Interleukin 8
Lung diseases
Lung diseases, Obstructive
nanoemulsion
Nanoemulsions
Nanoparticles
Nicotiana
nutraceuticals
Obstructive lung disease
Oils & fats
Oxidants
Oxidative Stress
Oxidizing agents
Pharmacokinetics
Physiological aspects
phytoceuticals
Plant extracts
Platelet-derived growth factor
Proteins
Pulmonary Disease, Chronic Obstructive - metabolism
Relaxin
Respiratory diseases
Respiratory tract
Risk factors
Signal transduction
Signs and symptoms
Smoke
Smoking
Tumor necrosis factor-TNF
γ-Interferon
SummonAdditionalLinks – databaseName: DOAJ Directory of Open Access Journals
  dbid: DOA
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Nb9QwELVQT1wQUD4CLTICwSnUjp3YOaarVgWJclgq9RbZiQMRWW-1TUT7G_jTzDjpshEHLlzX3t3EMxO_58y8IeStboTSQHBiZkQSy6zRsbapjfGE33CXJiqIJH0-z84u5KfL9HKn1RfmhI3ywOPCHaW5rWyDSEE52E0aLSAkammMBepixVjmy5IdMjUCXwUEXYx6pAJ4_ZEfAPpIHiR1dnagINT_9-N4Zz-a50rubD6nD8mDCTXSYrzaR-Se84_JfuGBMa9u6Tsa8jjDAfk--VV8MxvMpKFf2o7C03PtVkOHh2K06AEhD4gu6aIN_W17R5er9Q8XYwuPytX0o2_AR8Z6Rmo8_MhNWwdxcLoMZSUUq3sAM9LW0-NFG58v-QdOi3bz09zSkyss8ejAp-nCdd31E3JxevJ1cRZPLRfiKhV5HxuUn5NSuiSrcyYgWDWsJFAK1uQ1kBcnDRPAMrKKCcOVVU7wmuVNCkRSJGktnpI9v_buOaEwwWruEu00QAjTaJ1pWZuKOytlLllE3tyZobwalTVKYCRorPKPsSJyjBbazkA17PAB-Eg5-Uj5Lx-JyHu0b4kxC0aszFR6ABeK6ldlATAKiDJPsogczGZCrFXz4TsPKadYvy4Thf3aGdfwP6-3w_hNzF_zbj3gHD2-5BIReTY61PaWRKZRlVBFRM1cbXbP8xHffg9K4CgWp7R48T8W6SW5nzAMWkzVOSB7_WZwhwC4evsqxNZvHOUmjQ
  priority: 102
  providerName: Directory of Open Access Journals
– databaseName: Health & Medical Collection
  dbid: 7X7
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9QwELagXLggoDwCBRmB4BQax07snFC6alWQKIel0t4iO3HaiGyy7CaC_gb-NDNOdrsREtfYGyU7D883mfmGkHeq5FIBwPEDzUNfxKXylYmMjxl-zWwUSkeS9PUiPr8UXxbRYky4bcayyq1PdI66aHPMkR-HEqdiB0ypT6ufPk6Nwq-r4wiNu-QeC-EoB32WC7nLsTgum5gPrKQc0P1x00MAJJgj1tk7hxxd_79Oee9UmlZM7h1BZw_JgzF2pOkg7Efkjm0ek8O0Ady8vKHvqavmdGnyQ_InvdJrrKeh36qagg9t7bKvMTVG0w7i5B5jTDqr3JTbztL5sv1hfRzkkduCfm5K0JShq5HqBm7yuyocRTidu-YSij0-EDnSqqEns8q_mLOPjKbV-pe-oacrbPSoQbPpzNb15gm5PDv9Pjv3x8ELfh7xpPM1ktAJIWwYF0nAwWQV_JMALIIyKQDCWKEDDlgjzgOumTTSclYESRkBnORhVPCn5KBpG_ucUNhgFLOhsgoCCV0qFStR6JxZI0QiAo-83YohWw38GhngEhRWdissj5yghHY7kBPbXWjXV9loYlmUmNyUGFNKC3FHqTg4z0JobQDkGq488gHlm6HlghBzPTYgwIMiB1aWQjAFcJmFsUeOJjvB4vLp8lZDstHiN9mtfnrkzW4Zf4lVbI1te9yjhk9d3CPPBoXavRKPFXITSo_IiapN3nm60lTXjg8cKeOk4i_-_1gvyf0wQKPEUpwjctCte_sKAqrOvHZW8xf6eB59
  priority: 102
  providerName: ProQuest
– databaseName: Scholars Portal Open Access Journals
  dbid: M48
  link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwdV1Nb9QwELVKkVAvCCgfKQUZgeCUksRO4hwQSletClLLYVmpt8hOnBKRddp0I7q_gT_NjJMsDR_XtZPdZGbs97wzbwh5I0oWCyA4ridZ4PKoFK5QoXLxhF_6OgxiK5J0ehadLPjn8_B8i4z9O4cXeP1Paof9pBZtfXBztf4IAf8BGSdQ9vemA1TDwbeSO-RuADsipnadDjC_h8Ex0HXWq5P-cckOuccigbJw8WRrsgr-f6_TtzaqaRLlrV3p-AG5P8BJmvb2f0i2tHlEdlMDVHq5pm-pTfC0J-e75Gd6IVtMsaFfqprCstroZVfjaRlNVwCdO4SddFbZxrcrTefL5rt2sbdHrgv6yZTgPH2hI5UGbnJTFVY1nM5tvQnFsh8Ak7Qy9HBWuWdz_8CnadX-kGt6dIm1HzU4O53pur5-TBbHR19nJ-7Qi8HNQ5asXIm6dJxzHURF4jGIYgEvFbiGVyYFsBrNpceAfkS5x6Qfq1gzv_CSMgSGyYKwYE_ItmmMfkYoTFDC14HQArCFLIWIBC9k7mvFecI9h7wezZBd9pIbGVAVtFv2224OOUQLbWagTLb9oGkvsiHqsjBRuSoRZsYaoEgpGKynBZdSAe9VTDjkHdo3Q_cCI-ZyqEmAH4qyWFkK-AoYtB9EDtmfzIQgzKfDo4dkow9nQYyN3D1fwPe82gzjlZjYZnTT4RzR__vFHPK0d6jNI41-6ZB44mqTZ56OmOqblQhHFblYsL3_3vM52Qk8DFFMzNkn26u20y8AXq3USxs7vwDaxiAs
  priority: 102
  providerName: Scholars Portal
Title Agarwood Oil Nanoemulsion Attenuates Cigarette Smoke-Induced Inflammation and Oxidative Stress Markers in BCi-NS1.1 Airway Epithelial Cells
URI https://www.ncbi.nlm.nih.gov/pubmed/36839377
https://www.proquest.com/docview/2779590188
https://search.proquest.com/docview/2780066573
https://pubmed.ncbi.nlm.nih.gov/PMC9959783
https://doaj.org/article/59bcbf00837e426f83376d4aab211b38
Volume 15
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Pb9MwFLa2ceGCBuNH2KiMQHBKm8RO7BzTqmMgtUyUSb1FduJsEWlada1gfwP_NO85aWnEjUsOtfOr7z37-5z3PhPyXhZMSCA4rqdY4PKokK7UoXZxhV_5JgyEFUmaTKOrG_5lHs6PSLirhbFJ-5ku-3W16Nflnc2tXC2ywS5PbHA9GaFGlpBscEyOYfo9oOgN5hXAzVkjRcqA0g_qLaAeDr6HEqEskqgBJzrzkJXr_3dQPpiVuhmTB1PQ5Sl50mJHmjTP-JQcmfoZOUtq4M2LB_qB2mxOu0x-Rn4nt2qN-TT0a1lRGEOXZrGtcGmMJhvAyVvEmHRU2l1uN4bOFssfxsWNPDKT0891AZ7SVDVSVcNFfpW5lQinM1tcQrHGB5AjLWs6HJXudOb3fZqU65_qgY5XWOhRgWfTkamq--fk5nL8fXTlthsvuFnI4o2rUISOc26CKI89BiEr4U8FYuEVcQ4UxnDlMeAaUeYx5QstDPNzLy5CoJMsCHP2gpzUy9q8IhQ6aOmbQBoJQEIVUkaS5yrzjeY85p5D3u3MkK4afY0UeAnaLf1rN4cM0UL7HqiJbX9Yrm_T1jPSMNaZLhBTCgO4o5AMBs-cK6WB5GomHfIR7Zti5IIRM9UWIMCDogZWmgCYArrsB5FDLjo9IeKybvPOQ9I24u_TQOCu7Z4v4T5v9814Jmax1Wa5xT6y-dTFHPKycaj9K-380iGi42qdd-62QHhYPfA2HF7_95nn5HHgYbxils4FOdmst-YNYK2N7kGEzUWPPBqOp9ffenbFAo6f5j4cJ1z2bOz9AeB9LNI
link.rule.ids 230,314,727,780,784,864,885,2102,2221,12056,21388,24318,27924,27925,31719,31720,33744,33745,43310,43805,53791,53793,73745,74302
linkProvider National Library of Medicine
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9NAEB5BeoALAsrDpcAiEJxMbe_aXp-QE6VKoQ2ItFJv1tpeF4vETvMQ9Dfwp5lZO2ksJK7ejWVnHvvNeOYbgHey4KHEAMd2FPdsERTSlqmf2pThV672vdCQJJ2Ng9GF-HzpX7YJt2VbVrnxicZR53VGOfIjL6Sp2I4r5af5tU1To-jrajtC4y7sEXO634O9_nD87fs2y2LYbALe8JJyjO-PqjVCIOEaap2dk8gQ9v_rlnfOpW7N5M4hdPwQHrTokcWNuB_BHV09hv24wsh5dsPeM1PPaRLl-_AnvlILqqhhX8spQy9a69l6SskxFq8QKa8JZbJBaebcrjSbzOqf2qZRHpnO2UlVoK40fY1MVXiT32VuSMLZxLSXMOryQezIyor1B6U9nrgfXRaXi1_qhg3n1OoxRd1mAz2dLp_AxfHwfDCy29ELdubzaGUroqETQmgvyCOHo9FK_CcxtHCKKMcgRgvlcIw2gszhyg3TUHM3d6LCx4CSe37On0Kvqiv9HBhuSKWrPaklQglVSBlIkavM1akQkXAseLsRQzJvGDYSjExIWMmtsCzok4S2O4gV21yoF1dJa2SJH6VZWhCqDDUij0JydJ-5UCrFMDfl0oIPJN-EbBeFmKm2BQEflFiwkhjhFAbMrhdYcNjZiTaXdZc3GpK0Nr9MbjXUgjfbZfol1bFVul7THtl87OIWPGsUavtKPJDEThhaEHZUrfPO3ZWq_GEYwYk0LpT84P-P9Rrujc7PTpPTk_GXF3Dfc8hEqTDnEHqrxVq_RHi1Sl-1NvQXdDki0w
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV1Lb9NAEB5BKiEuCChQlwKLQHAytb1re31CTkjU8ggVoVJv1tpeF6uJHfIQ9Dfwp5lZO2ksJK7ejWVnHjvfeOYbgNey4KFEgGM7inu2CAppy9RPbcrwK1f7XmhIkr6Mg5Nz8fHCv2jrn5ZtWeXGJxpHndcZ5ciPvZCmYjsuAraiLYs4-zB6P_9p0wQp-tLajtO4DXt4KjpeD_b6w_HZt23GxTDbBLzhKOWI9Y-rNYZDwjU0OzunkiHv_9dF75xR3frJnQNpdB_utZEkixvRP4BbunoI-3GFKHp2zd4wU9tpkub78Ce-VAuqrmFfyylDj1rr2XpKiTIWrzBqXlPEyQalmXm70mwyq6-0TWM9Mp2z06pAvWl6HJmq8Ca_y9wQhrOJaTVh1PGDcSQrK9YflPZ44r5zWVwufqlrNpxT28cU9ZwN9HS6fATno-H3wYndjmGwM59HK1sRJZ0QQntBHjkcDVjiP4kwwymiHAGNFsrhiDyCzOHKDdNQczd3osJHcMk9P-ePoVfVlT4AhhtS6WpPaolhhSqkDKTIVebqVIhIOBa82oghmTdsGwmiFBJWciMsC_okoe0OYsg2F-rFZdIaXOJHaZYWFGGGGqOQQnJ0pblQKkXIm3JpwVuSb0J2jELMVNuOgA9KjFhJjEqE4Nn1AguOOjvR_rLu8kZDktb-l8mNtlrwcrtMv6SatkrXa9ojmw9f3IInjUJtX4kHkpgKQwvCjqp13rm7UpU_DDs4EciFkh_-_7FewB00n-Tz6fjTU7jrOWStVKNzBL3VYq2fYaS1Sp-3JvQXFbQnAA
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Agarwood+Oil+Nanoemulsion+Attenuates+Cigarette+Smoke-Induced+Inflammation+and+Oxidative+Stress+Markers+in+BCi-NS1.1+Airway+Epithelial+Cells&rft.jtitle=Nutrients&rft.au=De+Rubis%2C+Gabriele&rft.au=Paudel%2C+Keshav+Raj&rft.au=Manandhar%2C+Bikash&rft.au=Singh%2C+Sachin+Kumar&rft.date=2023-02-01&rft.eissn=2072-6643&rft.volume=15&rft.issue=4&rft_id=info:doi/10.3390%2Fnu15041019&rft_id=info%3Apmid%2F36839377&rft.externalDocID=36839377
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2072-6643&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2072-6643&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2072-6643&client=summon