Drug Discovery and Development Targeting Dementia

Dementia, most often associated with neurodegenerative diseases, affects millions of people worldwide, predominantly the elderly. Unfortunately, no treatment is still available. Therefore, there is an urgent need to address this situation. This review presents the state of the art of drug discovery...

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Published inPharmaceuticals (Basel, Switzerland) Vol. 16; no. 2; p. 151
Main Authors Zagórska, Agnieszka, Czopek, Anna, Fryc, Monika, Jaromin, Anna, Boyd, Ben J
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 19.01.2023
MDPI
Subjects
Activities of daily living
Alzheimer's disease
Biomarkers
Brain research
Causes of
Clinical trials
Dementia
Development and progression
Diabetes
Drug discovery
drug discovery and development
Drug targeting
Drug therapy
Drugs
FDA approval
Forecasts and trends
Hypotheses
Ischemia
nanocarriers
Pathogenesis
Pathology
Pathophysiology
Proteins
R&D
Research & development
Review
Poland
dementia
drug discovery and development
nanocarriers
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Abstract Dementia, most often associated with neurodegenerative diseases, affects millions of people worldwide, predominantly the elderly. Unfortunately, no treatment is still available. Therefore, there is an urgent need to address this situation. This review presents the state of the art of drug discovery and developments in targeting dementia. Several approaches are discussed, such as drug repurposing, the use of small molecules, and phosphodiesterase inhibitors. Furthermore, the review also provides insights into clinical trials of these molecules. Emphasis has been placed on small molecules and multi-target-directed ligands, as well as disease-modifying therapies. Finally, attention is drawn to the possibilities of applications of nanotechnology in managing dementia.
AbstractList Dementia, most often associated with neurodegenerative diseases, affects millions of people worldwide, predominantly the elderly. Unfortunately, no treatment is still available. Therefore, there is an urgent need to address this situation. This review presents the state of the art of drug discovery and developments in targeting dementia. Several approaches are discussed, such as drug repurposing, the use of small molecules, and phosphodiesterase inhibitors. Furthermore, the review also provides insights into clinical trials of these molecules. Emphasis has been placed on small molecules and multi-target-directed ligands, as well as disease-modifying therapies. Finally, attention is drawn to the possibilities of applications of nanotechnology in managing dementia.
Audience Academic
Author Jaromin, Anna
Zagórska, Agnieszka
Boyd, Ben J
Fryc, Monika
Czopek, Anna
AuthorAffiliation 3 Department of Pharmacy, University of Copenhagen, Universitetsparken 2, 2100 Copenhagen, Denmark
4 Drug Delivery Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, VIC 3052, Australia
1 Department of Medicinal Chemistry, Jagiellonian University Medical College, Medyczna 9, 30-688 Kraków, Poland
2 Department of Lipids and Liposomes, Faculty of Biotechnology, University of Wrocław, Joliot-Curie 14a, 50-383 Wrocław, Poland
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Keywords dementia
drug discovery and development
nanocarriers
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Snippet Dementia, most often associated with neurodegenerative diseases, affects millions of people worldwide, predominantly the elderly. Unfortunately, no treatment...
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StartPage 151
SubjectTerms Activities of daily living
Alzheimer's disease
Biomarkers
Brain research
Causes of
Clinical trials
Dementia
Development and progression
Diabetes
Drug discovery
drug discovery and development
Drug targeting
Drug therapy
Drugs
FDA approval
Forecasts and trends
Hypotheses
Ischemia
nanocarriers
Pathogenesis
Pathology
Pathophysiology
Proteins
R&D
Research & development
Review
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Title Drug Discovery and Development Targeting Dementia
URI https://www.ncbi.nlm.nih.gov/pubmed/37259302
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Volume 16
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