A miR-130a-YAP positive feedback loop promotes organ size and tumorigenesis

• Published in: Cell research Vol. 25; no. 9; pp. 997 - 1012
• Main Authors: Shen, Shuying, Guo, Xiaocan, Yan, Huan, Lu, Yi, Ji, Xinyan, Li, Li, Liang, Tingbo, Zhou, Dawang, Feng, Xin-Hua, Zhao, Jonathan C, Yu, Jindan, Gong, Xing-Guo, Zhang, Lei, Zhao, Bin
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.09.2015; Nature Publishing Group
• Subjects: 631/337/384/331; 631/80/86; 692/420/755; Adaptor Proteins, Signal Transducing - antagonists & inhibitors; Adaptor Proteins, Signal Transducing - genetics; Adaptor Proteins, Signal Transducing - metabolism; Animals; Base Sequence; Biomedical and Life Sciences; Carcinogenesis; Cell Biology; Cell Line, Tumor; Cell Proliferation; Cysteine-Rich Protein 61 - antagonists & inhibitors; Cysteine-Rich Protein 61 - genetics; Cysteine-Rich Protein 61 - metabolism; Drosophila - metabolism; Drosophila Proteins - metabolism; Hep G2 Cells; Humans; Inactivation; Life Sciences; Male; Mice; Mice, Inbred ICR; Mice, Nude; MicroRNAs - antagonists & inhibitors; MicroRNAs - metabolism; Organ Size - genetics; Original; original-article; Phosphoproteins - antagonists & inhibitors; Phosphoproteins - genetics; Phosphoproteins - metabolism; Sequence Alignment; Signal Transduction; Transcription Factors - antagonists & inhibitors; Transcription Factors - genetics; Transcription Factors - metabolism; Transplantation, Heterologous; 信号通路; 反馈回路; 器官; 正反馈机制; 活性抑制剂; 激活因子; 直接诱导; 肿瘤发生; microRNA; YAP; tumorigenesis; organ size; Hippo

Organ size determination is one of the most intriguing unsolved mysteries in biology. Aberrant activation of the major effector and transcription co-activator YAP in the Hippo pathway causes drastic organ enlargement in development and underlies tumorigenesis in many human cancers. However, how robu...