Cerebrospinal Fluid Inflammatory Cytokines and Aggression in Personality Disordered Subjects

• Published in: The international journal of neuropsychopharmacology Vol. 18; no. 7; p. pyv001
• Main Authors: Coccaro, Emil F., Lee, Royce, Coussons-Read, Mary
• Format: Journal Article
• Language: English
• Published: US Oxford University Press 01.05.2015
• Subjects: Adult; Aggression - psychology; Cerebrospinal fluid; Cytokines; Cytokines - cerebrospinal fluid; Diagnostic and Statistical Manual of Mental Disorders; Dopamine - cerebrospinal fluid; Female; Human subjects; Humans; Impulsive Behavior; Interleukin-6 - cerebrospinal fluid; Male; Middle Aged; Personality; Personality Disorders - cerebrospinal fluid; Personality Disorders - psychology; Predictive Value of Tests; Psychiatric Status Rating Scales - standards; Receptors, Interleukin-1 Type II - analysis; Serotonin - cerebrospinal fluid; Spinal Puncture - methods; Suicidal Ideation; Young Adult; sIL-1RII; impulsivity; aggression; personality; IL-6; CSF

Background:Neurochemical studies have pointed to a modulatory role in human aggression for a variety of central neurotransmitters and neuromodulators such as cytokines. While animal studies of cytokines suggest an aggression-facilitating role for central cytokines, especially for interleukin-1β and...