DNA repair dysregulation from cancer driver to therapeutic target

• Published in: Nature reviews. Cancer Vol. 12; no. 12; pp. 801 - 817
• Main Author: Curtin, Nicola J.
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.12.2012; Nature Publishing Group
• Subjects: 631/337/1427/2566; 692/699/67/1059/602; Analysis; Animals; Antineoplastic Agents - pharmacokinetics; Antineoplastic Agents - pharmacology; Biomarkers - analysis; Biomedical and Life Sciences; Biomedicine; Cancer; Cancer Research; Care and treatment; Cell cycle; Cell Cycle Checkpoints - genetics; Cell survival; Cellular signal transduction; Chemotherapy; Development and progression; DNA Damage; DNA repair; DNA Repair - drug effects; Genetic aspects; Genomics; Homologous Recombination; Humans; Neoplasms - drug therapy; Neoplasms - genetics; Physiological aspects; Radiotherapy; review-article; Signal transduction; Signal Transduction - genetics; Stress; Therapeutic applications

Key Points The DNA damage response (DDR) coordinates the repair of DNA and the activation of cell cycle checkpoints to arrest the cell to allow time for repair. DNA is subject to a high level of endogenous damage and the DDR is essential for the maintenance of genomic stability and survival. Dysregu...