Autotaxin Is Overexpressed in Glioblastoma Multiforme and Contributes to Cell Motility of Glioblastoma by Converting Lysophosphatidylcholine TO Lysophosphatidic Acid

• Published in: The Journal of biological chemistry Vol. 281; no. 25; pp. 17492 - 17500
• Main Authors: Kishi, Yasuhiro, Okudaira, Shinichi, Tanaka, Masayuki, Hama, Kotaro, Shida, Dai, Kitayama, Joji, Yamori, Takao, Aoki, Junken, Fujimaki, Takamitsu, Arai, Hiroyuki
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 23.06.2006; American Society for Biochemistry and Molecular Biology
• Subjects: Blotting, Western; Brain - metabolism; Cell Line, Tumor; Cell Movement; Electrophoresis, Polyacrylamide Gel; Gene Expression Regulation, Neoplastic; Glioblastoma - metabolism; Humans; Lysophosphatidylcholines - metabolism; Lysophospholipids - metabolism; Models, Biological; Multienzyme Complexes - biosynthesis; Multienzyme Complexes - physiology; Phosphodiesterase I - biosynthesis; Phosphodiesterase I - physiology; Phosphoric Diester Hydrolases - chemistry; Pyrophosphatases - biosynthesis; Pyrophosphatases - physiology; Time Factors; Transfection

Autotaxin (ATX) is a multifunctional phosphodiesterase originally isolated from melanoma cells as a potent cell motility-stimulating factor. ATX is identical to lysophospholipase D, which produces a bioactive phospholipid, lysophosphatidic acid (LPA), from lysophosphatidylcholine (LPC). Although enh...