Urinary type IV collagen is related to left ventricular diastolic function and brain natriuretic peptide in hypertensive patients with prediabetes

• Published in: Journal of diabetes and its complications Vol. 28; no. 6; pp. 824 - 830
• Main Authors: Iida, Masato, Yamamoto, Mitsuru, Ishiguro, Yuko S., Yamazaki, Masatoshi, Ueda, Norihiro, Honjo, Haruo, Kamiya, Kaichirou
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.11.2014; Elsevier Limited
• Subjects: Aged; Aged, 80 and over; Albuminuria - blood; Albuminuria - complications; Albuminuria - physiopathology; Biomarkers; Blood Glucose - metabolism; Blood pressure; BNP; Cardiomyopathy; Collagen; Collagen Type IV - urine; Diabetes; Echocardiography; Endocrinology & Metabolism; Female; Flow velocity; Gender; Glomerular Filtration Rate; Heart attacks; Humans; Hypertension; Hypertension - blood; Hypertension - complications; Hypertension - physiopathology; Hypertension - urine; Left ventricular diastolic function; Male; Natriuretic Peptide, Brain - blood; Patients; Peptides; Prediabetes; Prediabetic State - blood; Prediabetic State - complications; Prediabetic State - physiopathology; Prediabetic State - urine; Rodents; Studies; Urinary type IV collagen; Ventricular Dysfunction, Left - blood; Ventricular Dysfunction, Left - physiopathology; Ventricular Dysfunction, Left - urine; Ventricular Function, Left - physiology; Hypertension; Left ventricular diastolic function; Echocardiography; Prediabetes; BNP; Urinary type IV collagen

Urinary type IV collagen is an early biomarker of diabetic nephropathy. Concomitant prediabetes (the early stage of diabetes) was associated with left ventricular (LV) diastolic dysfunction and increased brain natriuretic peptide (BNP) in hypertensive patients. We hypothesized that urinary type IV c...