Cross-specificity of protective human antibodies against Klebsiella pneumoniae LPS O-antigen

• Published in: Nature immunology Vol. 19; no. 6; pp. 617 - 624
• Main Authors: Rollenske, Tim, Szijarto, Valeria, Lukasiewicz, Jolanta, Guachalla, Luis M., Stojkovic, Katarina, Hartl, Katharina, Stulik, Lukas, Kocher, Simone, Lasitschka, Felix, Al-Saeedi, Mohammed, Schröder-Braunstein, Jutta, von Frankenberg, Moritz, Gaebelein, Gereon, Hoffmann, Peter, Klein, Sabrina, Heeg, Klaus, Nagy, Eszter, Nagy, Gabor, Wardemann, Hedda
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.06.2018; Nature Publishing Group
• Subjects: 631/250/2152/2153/1291; 631/250/2499; 631/250/347; Antibiotic resistance; Antibodies; Antigenic determinants; Antigens; B cells; Bacterial diseases; Bacterial infections; Biomedical and Life Sciences; Biomedicine; Drug therapy; Epitopes; Immune response; Immune response (humoral); Immunoglobulin A; Immunoglobulin M; Immunoglobulins; Immunological memory; Immunology; Infection; Infection control; Infectious Diseases; Intestine; Klebsiella infections; Klebsiella pneumoniae; Lipopolysaccharides; Lymphocytes B; Memory cells; Microbial drug resistance; Microbial polysaccharides; Microbiota; Microbiota (Symbiotic organisms); Microorganisms; Mitogens; Monoclonal antibodies; Nosocomial infection; O antigens; Opportunist infection; Pathogenic microorganisms; Pathogens; Peripheral blood; Pneumonia; Polysaccharides; Prevention; Risk factors; Serotypes; Surface antigens; T cells

Humoral immune responses to microbial polysaccharide surface antigens can prevent bacterial infection but are typically strain specific and fail to mediate broad protection against different serotypes. Here we describe a panel of affinity-matured monoclonal human antibodies from peripheral blood imm...