Abiraterone and Increased Survival in Metastatic Prostate Cancer

• Published in: The New England journal of medicine Vol. 364; no. 21; pp. 1995 - 2005
• Main Authors: de Bono, Johann S, Logothetis, Christopher J, Molina, Arturo, Fizazi, Karim, North, Scott, Chu, Luis, Chi, Kim N, Jones, Robert J, Goodman, Oscar B, Saad, Fred, Staffurth, John N, Mainwaring, Paul, Harland, Stephen, Flaig, Thomas W, Hutson, Thomas E, Cheng, Tina, Patterson, Helen, Hainsworth, John D, Ryan, Charles J, Sternberg, Cora N, Ellard, Susan L, Fléchon, Aude, Saleh, Mansoor, Scholz, Mark, Efstathiou, Eleni, Zivi, Andrea, Bianchini, Diletta, Loriot, Yohann, Chieffo, Nicole, Kheoh, Thian, Haqq, Christopher M, Scher, Howard I
• Format: Journal Article
• Language: English
• Published: Waltham, MA Massachusetts Medical Society 26.05.2011
• Subjects: Acetic acid; Aged; Androgen Antagonists - adverse effects; Androgen Antagonists - therapeutic use; Androgens; Androgens - biosynthesis; Androstenes; Androstenols - adverse effects; Androstenols - therapeutic use; Antineoplastic Combined Chemotherapy Protocols - adverse effects; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Biological and medical sciences; Biosynthesis; Biotechnology; Cancer therapies; Castration; Chemotherapy; Disease Progression; Double-Blind Method; Fatigue - chemically induced; Fees & charges; General aspects; Gynecology. Andrology. Obstetrics; Humans; Hypertension; Hypokalemia; Kaplan-Meier Estimate; Laboratories; Male; Male genital diseases; Medical research; Medical sciences; Metastases; Middle Aged; Neoplasm Metastasis; Nephrology. Urinary tract diseases; Oncology; Pain; Patients; Prednisone; Prednisone - therapeutic use; Prostate cancer; Prostate-specific antigen; Prostatic Neoplasms - drug therapy; Prostatic Neoplasms - mortality; Prostatic Neoplasms - pathology; Steroid 17-alpha-Hydroxylase - antagonists & inhibitors; Survival; Survival Analysis; Treatment Outcome; Tumors; Tumors of the urinary system; Urinary tract. Prostate gland; Urinary system disease; Prostate disease; Abiraterone; Antiandrogen; Antihormone; Malignant tumor; Metastasis; Survival; Medicine; Advanced stage; Metastatic; Male genital diseases; Prostate cancer; Cancer

In this study, abiraterone acetate inhibited androgen synthesis and prolonged survival by 4 months among men with castration-resistant prostate cancer that had progressed with docetaxel chemotherapy. For the past 70 years, depleting or blocking the action of androgens has been the standard of care f...