Association of neutrophil-lymphocyte ratio with metabolic syndrome and its components in Asian Indians (CURES-143)

Metabolic syndrome (MS) is the state of chronic low grade inflammation. This study looks at the relationship of neutrophil-lymphocyte ratio (NLR) in subjects with and without MS in Asian Indians. Study subjects (n=754) were recruited from the Chennai Urban Rural Epidemiology Study. MS was defined us...

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Published inJournal of diabetes and its complications Vol. 30; no. 8; pp. 1525 - 1529
Main Authors Surendar, Jayagopi, Indulekha, Karunakaran, Mohan, Viswanathan, Pradeepa, Rajendra
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.11.2016
Elsevier Limited
Subjects
Adult
Asian Indians
Endocrinology & Metabolism
Female
Humans
India
Low density lipoprotein
Lymphocytes
Lymphocytes - cytology
Male
Metabolic syndrome
Metabolic Syndrome - ethnology
Metabolic Syndrome - physiopathology
Middle Aged
Neutrophils
Neutrophils - cytology
NLR
Risk Factors
Studies
Metabolic syndrome
NLR
Lymphocytes
Asian Indians
Neutrophils
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Summary:Metabolic syndrome (MS) is the state of chronic low grade inflammation. This study looks at the relationship of neutrophil-lymphocyte ratio (NLR) in subjects with and without MS in Asian Indians. Study subjects (n=754) were recruited from the Chennai Urban Rural Epidemiology Study. MS was defined using the National Cholesterol Education Program-Adult Treatment Panel (NCEP-ATP) III criteria modified for waist according to World Health Organization Asia Pacific guidelines. A complete hemogram was done in all subjects using a five-part hematology analyzer (model SF-3000; Sysmex, Kobe, Japan). The NLR was calculated as the ratio between counts for neutrophils and total lymphocytes in subjects with (n=422) and without (n332) MS and correlated with number of metabolic abnormalities in those with MS. Subjects with five metabolic abnormalities had the highest NLR, and with decreasing number of metabolic abnormalities, the NLR decreased linearly (p for trend <0.001). Logistic regression analysis revealed that even after adjusting for age, gender and body mass index, MS was strongly associated with NLR (p<0.001). Among Asian Indians, NLR is correlated with MS and also with the number of metabolic abnormalities.
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ISSN:1056-8727
1873-460X
1873-460X
DOI:10.1016/j.jdiacomp.2016.08.006