The Relationship Between Tramadol-Induced Oxidative Testis Injury and Reproductive Function Disorder and Adenosine Triphosphate

• Published in: Life (Basel, Switzerland) Vol. 15; no. 7; p. 1078
• Main Authors: Bedir, Fevzi, Kocatürk, Hüseyin, Altay, Mehmet Sefa, Mammadov, Renad, Süleyman, Bahadır, Coban, Taha Abdulkadir, Yazici, Gülce Naz, Bulut, Seval, Süleyman, Halis
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 06.07.2025; MDPI
• Subjects: Adenosine; Adenosine triphosphate; Analgesics; Animals; Antibodies; antioxidant; Antioxidants; ATP; Basement membranes; Connective tissues; Cytokines; Distilled water; Drinking water; Enzymes; Females; Germ cells; Hyperplasia; Infertility; Inflammation; Medical research; Muscle proteins; Narcotics; Oral administration; Oxidants; Oxidative stress; Oxidizing agents; Pathogenesis; pro-inflammatory; rat; Reproductive disorders; Seminiferous tubule; Software; Sperm; Testes; Tissues; Tramadol; Tumor necrosis factor-TNF; Illinois; Turkey; United States > US; tramadol; antioxidant; rat; infertility; ATP; pro-inflammatory

Tramadol, a central analgesic drug, is used to treat moderate to severe pain but can cause reproductive disorders. The pathogenesis of tramadol-induced reproductive damage may involve increased oxidative stress, pro-inflammatory cytokines, ATP depletion, and reduced antioxidant levels. In this study...