Dietary Responses of Dementia-Related Genes Encoding Metabolic Enzymes

The age-related loss of the cognitive function is a growing concern for global populations. Many factors that determine cognitive resilience or dementia also have metabolic functions. However, this duality is not universally appreciated when the action of that factor occurs in tissues external to th...

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Published inNutrients Vol. 15; no. 3; p. 644
Main Authors Parnell, Laurence D, Magadmi, Rozana, Zwanger, Sloane, Shukitt-Hale, Barbara, Lai, Chao-Qiang, Ordovás, José M
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 27.01.2023
MDPI
Subjects
Age
Alzheimer Disease - genetics
Alzheimer Disease - psychology
Alzheimer's disease
Blood
Brain
Broccoli
Cognition & reasoning
Cognition - physiology
Cognitive ability
Dementia
Dementia disorders
Dementia, Vascular
Diet
Enzymatic activity
Enzyme activity
Enzymes
Epidemiology
Flavonoids
Food intake
Gene expression
Genes
gene–diet interaction
Genotypes
Heart
Humans
Kinases
Lifestyles
metabolic enzyme
Metabolism
Metabolites
Mortality
Nutrients
Nutrition research
Offspring
Palmitic acid
Parkinson's disease
Proteins
Sleep
Taurine
Tissues
Vascular dementia
United States
United States > US
gene–diet interaction
dementia
metabolic enzyme
taurine
diet
flavonoids
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Abstract The age-related loss of the cognitive function is a growing concern for global populations. Many factors that determine cognitive resilience or dementia also have metabolic functions. However, this duality is not universally appreciated when the action of that factor occurs in tissues external to the brain. Thus, we examined a set of genes involved in dementia, i.e., those related to vascular dementia, Alzheimer's disease, Parkinson's disease, and the human metabolism for activity in 12 metabolically active tissues. Mining the Genotype-Tissue Expression (GTEx) data showed that most of these metabolism-dementia (MD) genes (62 of 93, 67%) exhibit a higher median expression in any of the metabolically active tissues than in the brain. After identifying that several MD genes served as blood-based biomarkers of longevity in other studies, we examined the impact of the intake of food, nutrients, and other dietary factors on the expression of MD genes in whole blood in the Framingham Offspring Study ( = 2134). We observed positive correlations between flavonoids and , taurine and , broccoli and , and myricetin and ( < 2.09 × 10 ). In contrast, dairy protein, palmitic acid, and pie were negatively correlated, respectively, with the expression of , , and , among others ( < 2.92 × 10 ). The results of this investigation underscore the potential contributions of metabolic enzyme activity in non-brain tissues to the risk of dementia. Specific epidemiological or intervention studies could be designed using specific foods and nutrients or even dietary patterns focused on these foods and nutrients that influence the expression of some MD genes to verify the findings presented here.
AbstractList The age-related loss of the cognitive function is a growing concern for global populations. Many factors that determine cognitive resilience or dementia also have metabolic functions. However, this duality is not universally appreciated when the action of that factor occurs in tissues external to the brain. Thus, we examined a set of genes involved in dementia, i.e., those related to vascular dementia, Alzheimer’s disease, Parkinson’s disease, and the human metabolism for activity in 12 metabolically active tissues. Mining the Genotype-Tissue Expression (GTEx) data showed that most of these metabolism–dementia (MD) genes (62 of 93, 67%) exhibit a higher median expression in any of the metabolically active tissues than in the brain. After identifying that several MD genes served as blood-based biomarkers of longevity in other studies, we examined the impact of the intake of food, nutrients, and other dietary factors on the expression of MD genes in whole blood in the Framingham Offspring Study (n = 2134). We observed positive correlations between flavonoids and HMOX1, taurine and UQCRC1, broccoli and SLC10A2, and myricetin and SLC9A8 (p < 2.09 × 10−4). In contrast, dairy protein, palmitic acid, and pie were negatively correlated, respectively, with the expression of IGF1R, CSF1R, and SLC9A8, among others (p < 2.92 × 10−4). The results of this investigation underscore the potential contributions of metabolic enzyme activity in non-brain tissues to the risk of dementia. Specific epidemiological or intervention studies could be designed using specific foods and nutrients or even dietary patterns focused on these foods and nutrients that influence the expression of some MD genes to verify the findings presented here.
The age-related loss of the cognitive function is a growing concern for global populations. Many factors that determine cognitive resilience or dementia also have metabolic functions. However, this duality is not universally appreciated when the action of that factor occurs in tissues external to the brain. Thus, we examined a set of genes involved in dementia, i.e., those related to vascular dementia, Alzheimer's disease, Parkinson's disease, and the human metabolism for activity in 12 metabolically active tissues. Mining the Genotype-Tissue Expression (GTEx) data showed that most of these metabolism-dementia (MD) genes (62 of 93, 67%) exhibit a higher median expression in any of the metabolically active tissues than in the brain. After identifying that several MD genes served as blood-based biomarkers of longevity in other studies, we examined the impact of the intake of food, nutrients, and other dietary factors on the expression of MD genes in whole blood in the Framingham Offspring Study (n = 2134). We observed positive correlations between flavonoids and HMOX1, taurine and UQCRC1, broccoli and SLC10A2, and myricetin and SLC9A8 (p < 2.09 × 10-4). In contrast, dairy protein, palmitic acid, and pie were negatively correlated, respectively, with the expression of IGF1R, CSF1R, and SLC9A8, among others (p < 2.92 × 10-4). The results of this investigation underscore the potential contributions of metabolic enzyme activity in non-brain tissues to the risk of dementia. Specific epidemiological or intervention studies could be designed using specific foods and nutrients or even dietary patterns focused on these foods and nutrients that influence the expression of some MD genes to verify the findings presented here.The age-related loss of the cognitive function is a growing concern for global populations. Many factors that determine cognitive resilience or dementia also have metabolic functions. However, this duality is not universally appreciated when the action of that factor occurs in tissues external to the brain. Thus, we examined a set of genes involved in dementia, i.e., those related to vascular dementia, Alzheimer's disease, Parkinson's disease, and the human metabolism for activity in 12 metabolically active tissues. Mining the Genotype-Tissue Expression (GTEx) data showed that most of these metabolism-dementia (MD) genes (62 of 93, 67%) exhibit a higher median expression in any of the metabolically active tissues than in the brain. After identifying that several MD genes served as blood-based biomarkers of longevity in other studies, we examined the impact of the intake of food, nutrients, and other dietary factors on the expression of MD genes in whole blood in the Framingham Offspring Study (n = 2134). We observed positive correlations between flavonoids and HMOX1, taurine and UQCRC1, broccoli and SLC10A2, and myricetin and SLC9A8 (p < 2.09 × 10-4). In contrast, dairy protein, palmitic acid, and pie were negatively correlated, respectively, with the expression of IGF1R, CSF1R, and SLC9A8, among others (p < 2.92 × 10-4). The results of this investigation underscore the potential contributions of metabolic enzyme activity in non-brain tissues to the risk of dementia. Specific epidemiological or intervention studies could be designed using specific foods and nutrients or even dietary patterns focused on these foods and nutrients that influence the expression of some MD genes to verify the findings presented here.
The age-related loss of the cognitive function is a growing concern for global populations. Many factors that determine cognitive resilience or dementia also have metabolic functions. However, this duality is not universally appreciated when the action of that factor occurs in tissues external to the brain. Thus, we examined a set of genes involved in dementia, i.e., those related to vascular dementia, Alzheimer's disease, Parkinson's disease, and the human metabolism for activity in 12 metabolically active tissues. Mining the Genotype-Tissue Expression (GTEx) data showed that most of these metabolism-dementia (MD) genes (62 of 93, 67%) exhibit a higher median expression in any of the metabolically active tissues than in the brain. After identifying that several MD genes served as blood-based biomarkers of longevity in other studies, we examined the impact of the intake of food, nutrients, and other dietary factors on the expression of MD genes in whole blood in the Framingham Offspring Study ( = 2134). We observed positive correlations between flavonoids and , taurine and , broccoli and , and myricetin and ( < 2.09 × 10 ). In contrast, dairy protein, palmitic acid, and pie were negatively correlated, respectively, with the expression of , , and , among others ( < 2.92 × 10 ). The results of this investigation underscore the potential contributions of metabolic enzyme activity in non-brain tissues to the risk of dementia. Specific epidemiological or intervention studies could be designed using specific foods and nutrients or even dietary patterns focused on these foods and nutrients that influence the expression of some MD genes to verify the findings presented here.
The age-related loss of the cognitive function is a growing concern for global populations. Many factors that determine cognitive resilience or dementia also have metabolic functions. However, this duality is not universally appreciated when the action of that factor occurs in tissues external to the brain. Thus, we examined a set of genes involved in dementia, i.e., those related to vascular dementia, Alzheimer’s disease, Parkinson’s disease, and the human metabolism for activity in 12 metabolically active tissues. Mining the Genotype-Tissue Expression (GTEx) data showed that most of these metabolism–dementia (MD) genes (62 of 93, 67%) exhibit a higher median expression in any of the metabolically active tissues than in the brain. After identifying that several MD genes served as blood-based biomarkers of longevity in other studies, we examined the impact of the intake of food, nutrients, and other dietary factors on the expression of MD genes in whole blood in the Framingham Offspring Study (n = 2134). We observed positive correlations between flavonoids and HMOX1, taurine and UQCRC1, broccoli and SLC10A2, and myricetin and SLC9A8 (p < 2.09 × 10[sup.−4]). In contrast, dairy protein, palmitic acid, and pie were negatively correlated, respectively, with the expression of IGF1R, CSF1R, and SLC9A8, among others (p < 2.92 × 10[sup.−4]). The results of this investigation underscore the potential contributions of metabolic enzyme activity in non-brain tissues to the risk of dementia. Specific epidemiological or intervention studies could be designed using specific foods and nutrients or even dietary patterns focused on these foods and nutrients that influence the expression of some MD genes to verify the findings presented here.
The age-related loss of the cognitive function is a growing concern for global populations. Many factors that determine cognitive resilience or dementia also have metabolic functions. However, this duality is not universally appreciated when the action of that factor occurs in tissues external to the brain. Thus, we examined a set of genes involved in dementia, i.e., those related to vascular dementia, Alzheimer’s disease, Parkinson’s disease, and the human metabolism for activity in 12 metabolically active tissues. Mining the Genotype-Tissue Expression (GTEx) data showed that most of these metabolism–dementia (MD) genes (62 of 93, 67%) exhibit a higher median expression in any of the metabolically active tissues than in the brain. After identifying that several MD genes served as blood-based biomarkers of longevity in other studies, we examined the impact of the intake of food, nutrients, and other dietary factors on the expression of MD genes in whole blood in the Framingham Offspring Study ( n = 2134). We observed positive correlations between flavonoids and HMOX1 , taurine and UQCRC1 , broccoli and SLC10A2 , and myricetin and SLC9A8 ( p < 2.09 × 10 −4 ). In contrast, dairy protein, palmitic acid, and pie were negatively correlated, respectively, with the expression of IGF1R , CSF1R , and SLC9A8 , among others ( p < 2.92 × 10 −4 ). The results of this investigation underscore the potential contributions of metabolic enzyme activity in non-brain tissues to the risk of dementia. Specific epidemiological or intervention studies could be designed using specific foods and nutrients or even dietary patterns focused on these foods and nutrients that influence the expression of some MD genes to verify the findings presented here.
Audience Academic
Author Zwanger, Sloane
Magadmi, Rozana
Shukitt-Hale, Barbara
Lai, Chao-Qiang
Parnell, Laurence D
Ordovás, José M
AuthorAffiliation 3 Skidmore College, Saratoga Springs, NY 12866, USA
4 Neuroscience and Aging Laboratory, JM-USDA Human Nutrition Research Center on Aging at Tufts University, Agricultural Research Service, US Department of Agriculture, Boston, MA 02111, USA
2 Friedman School of Nutrition Science and Policy, Tufts University, Boston, MA 02111, USA
5 Nutrition and Genomics Laboratory, JM-USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
1 Nutrition and Genomics Laboratory, JM-USDA Human Nutrition Research Center on Aging at Tufts University, Agricultural Research Service, US Department of Agriculture, Boston, MA 02111, USA
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– name: 3 Skidmore College, Saratoga Springs, NY 12866, USA
– name: 4 Neuroscience and Aging Laboratory, JM-USDA Human Nutrition Research Center on Aging at Tufts University, Agricultural Research Service, US Department of Agriculture, Boston, MA 02111, USA
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  surname: Ordovás
  fullname: Ordovás, José M
  organization: Nutrition and Genomics Laboratory, JM-USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA
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Keywords gene–diet interaction
dementia
metabolic enzyme
taurine
diet
flavonoids
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Snippet The age-related loss of the cognitive function is a growing concern for global populations. Many factors that determine cognitive resilience or dementia also...
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SubjectTerms Age
Alzheimer Disease - genetics
Alzheimer Disease - psychology
Alzheimer's disease
Blood
Brain
Broccoli
Cognition & reasoning
Cognition - physiology
Cognitive ability
Dementia
Dementia disorders
Dementia, Vascular
Diet
Enzymatic activity
Enzyme activity
Enzymes
Epidemiology
Flavonoids
Food intake
Gene expression
Genes
gene–diet interaction
Genotypes
Heart
Humans
Kinases
Lifestyles
metabolic enzyme
Metabolism
Metabolites
Mortality
Nutrients
Nutrition research
Offspring
Palmitic acid
Parkinson's disease
Proteins
Sleep
Taurine
Tissues
Vascular dementia
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Title Dietary Responses of Dementia-Related Genes Encoding Metabolic Enzymes
URI https://www.ncbi.nlm.nih.gov/pubmed/36771351
https://www.proquest.com/docview/2774948399/abstract/
https://www.proquest.com/docview/2775622390/abstract/
https://pubmed.ncbi.nlm.nih.gov/PMC9921944
https://doaj.org/article/9282d85f442249f1a94ee45432808ef1
Volume 15
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