EGFR Protein Expression in Non-Small Cell Lung Cancer Predicts Response to an EGFR Tyrosine Kinase Inhibitor―A Novel Antibody for Immunohistochemistry or AQUA Technology

• Published in: Clinical cancer research Vol. 17; no. 24; pp. 7796 - 7807
• Main Authors: MASCAUX, Celine, WYNES, Murry W, NAGAO, Toshitaka, YOSHIDA, Koichi, OHIRA, Tatuso, IKEDA, Norihiko, HIRSCH, Fred R, KATO, Yasufumi, TRAN, Cindy, ASUNCION, Bernadette Reyna, ZHAO, Jason M, GUSTAVSON, Mark, RANGER-MOORE, Jim, GAIRE, Fabien, MATSUBAYASHI, Jun
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 15.12.2011
• Subjects: Adult; Aged; Aged, 80 and over; Antibodies; Antineoplastic agents; Binding Sites; Biological and medical sciences; Cancer; Carcinoma, Non-Small-Cell Lung - drug therapy; Carcinoma, Non-Small-Cell Lung - genetics; Carcinoma, Non-Small-Cell Lung - metabolism; Data processing; Epidermal growth factor receptors; Female; Fluorescent Antibody Technique - methods; Gefitinib; Humans; Image Processing, Computer-Assisted - methods; Immunohistochemistry; Immunohistochemistry - methods; Kaplan-Meier Estimate; Lung Neoplasms - drug therapy; Lung Neoplasms - genetics; Lung Neoplasms - metabolism; Male; Medical sciences; Middle Aged; Multivariate Analysis; Mutation; Non-small cell lung carcinoma; Outcome Assessment (Health Care) - statistics & numerical data; Pharmacology. Drug treatments; Pneumology; Prognosis; Proportional Hazards Models; Protein Kinase Inhibitors - therapeutic use; Protein-tyrosine kinase; Quinazolines - therapeutic use; Receptor, Epidermal Growth Factor - antagonists & inhibitors; Receptor, Epidermal Growth Factor - biosynthesis; Receptor, Epidermal Growth Factor - genetics; Survival; Therapeutic applications; Tissue Array Analysis; Tumors of the respiratory system and mediastinum; Immunohistochemistry; Lung disease; Respiratory disease; Antibody; Lung cancer; Malignant tumor; non-small cell lung carcinoma; Gene expression; EGFR tyrosine kinase inhibitor; Protein; Epidermal growth factor receptor; Anatomic pathology; Technology; Bronchus disease; Predictive factor; Cancer

Epidermal growth factor receptor (EGFR) protein expression in non-small cell lung cancer (NSCLC) is not recommended for predicting response to EGFR tyrosine kinase inhibitors (TKI) due to conflicting results, all using antibodies detecting EGFR external domain (ED). We tested the predictive value of...