Transferring Xenogenic Mitochondria Provides Neural Protection against Ischemic Stress in Ischemic Rat Brains

• Published in: Cell transplantation Vol. 25; no. 5; pp. 913 - 927
• Main Authors: Huang, Po-Jui, Kuo, Chi-Chung, Lee, Hsiu-Chin, Shen, Ching-I, Cheng, Fu-Chou, Wu, Shih-Fang, Chang, Jui-Chih, Pan, Hung-Chuan, Lin, Shinn-Zong, Liu, Chin-San, Su, Hong-Lin
• Format: Journal Article
• Language: English
• Published: Los Angeles, CA SAGE Publications 01.05.2016; Sage Publications Ltd; SAGE Publishing
• Subjects: Adenosine triphosphatase; Animals; Astrocytes; Brain - pathology; Brain Ischemia - pathology; Brain Ischemia - therapy; Cell death; Cell Death - physiology; Cell Line; Cell Survival; Central nervous system; Cricetinae; Electron transport; Electron Transport - physiology; Heart; Infarction, Middle Cerebral Artery - pathology; Infarction, Middle Cerebral Artery - therapy; Injections, Intra-Arterial; Internalization; Ischemia; Male; Mitochondria; Mitochondria - transplantation; Motor task performance; Neurons - cytology; Neuroprotection - physiology; Neuroprotective Agents - therapeutic use; Rats; Rats, Sprague-Dawley; Symbiosis; Transplantation, Heterologous; Neural protection; Mitochondria; Ischemic stroke; Mitochondria transfer

Transferring exogenous mitochondria has therapeutic effects on damaged heart, liver, and lung tissues. Whether this protective effect requires the symbiosis of exogenous mitochondria in host cells remains unknown. Here xenogenic mitochondria derived from a hamster cell line were applied to ischemic...