RAS and downstream RAF-MEK and PI3K-AKT signaling in neuronal development, function and dysfunction

• Published in: Biological chemistry Vol. 397; no. 3; pp. 215 - 222
• Main Author: Zhong, Jian
• Format: Journal Article
• Language: English
• Published: Germany De Gruyter 01.03.2016
• Subjects: Animals; axon; Cell Proliferation; Cell Survival; Extracellular Signal-Regulated MAP Kinases - metabolism; Humans; MAP kinase; Mitogen-Activated Protein Kinase Kinases - metabolism; Nerve Regeneration; neuron; Neurons - cytology; Neurons - metabolism; Neurons - pathology; Phosphatidylinositol 3-Kinases - metabolism; Proto-Oncogene Proteins c-akt - metabolism; raf Kinases - metabolism; ras Proteins - metabolism; RASopathies; regeneration; sensory function; Signal Transduction

In postmitotic neurons, the activation of RAS family small GTPases regulates survival, growth and differentiation. Dysregulation of RAS or its major effector pathway, the cascade of RAF-, mitogen-activated and extracellular-signal regulated kinase kinases (MEK), and extracellular-signal regulated ki...