RAS and downstream RAF-MEK and PI3K-AKT signaling in neuronal development, function and dysfunction

In postmitotic neurons, the activation of RAS family small GTPases regulates survival, growth and differentiation. Dysregulation of RAS or its major effector pathway, the cascade of RAF-, mitogen-activated and extracellular-signal regulated kinase kinases (MEK), and extracellular-signal regulated ki...

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Bibliographic Details
Published inBiological chemistry Vol. 397; no. 3; pp. 215 - 222
Main Author Zhong, Jian
Format Journal Article
LanguageEnglish
Published Germany De Gruyter 01.03.2016
Subjects
Animals
axon
Cell Proliferation
Cell Survival
Extracellular Signal-Regulated MAP Kinases - metabolism
Humans
MAP kinase
Mitogen-Activated Protein Kinase Kinases - metabolism
Nerve Regeneration
neuron
Neurons - cytology
Neurons - metabolism
Neurons - pathology
Phosphatidylinositol 3-Kinases - metabolism
Proto-Oncogene Proteins c-akt - metabolism
raf Kinases - metabolism
ras Proteins - metabolism
RASopathies
regeneration
sensory function
Signal Transduction
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Summary:In postmitotic neurons, the activation of RAS family small GTPases regulates survival, growth and differentiation. Dysregulation of RAS or its major effector pathway, the cascade of RAF-, mitogen-activated and extracellular-signal regulated kinase kinases (MEK), and extracellular-signal regulated kinases (ERK) causes the RASopathies, a group of neurodevelopmental disorders whose pathogenic mechanisms are the subject of intense research. I here summarize the functions of RAS-RAF-MEK-ERK signaling in neurons , and discuss perspectives for harnessing this pathway to enable novel treatments for nervous system injury, the RASopathies, and possibly other neurological conditions.
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ISSN:1431-6730
1437-4315
1437-4315
DOI:10.1515/hsz-2015-0270