Prior exposure to repeated morphine potentiates mechanical allodynia induced by peripheral inflammation and neuropathy

• Published in: Brain, behavior, and immunity Vol. 26; no. 8; pp. 1256 - 1264
• Main Authors: Loram, Lisa C, Grace, Peter M, Strand, Keith A, Taylor, Frederick R, Ellis, Amanda, Berkelhammer, Debra, Bowlin, Melissa, Skarda, Bryce, Maier, Steven F, Watkins, Linda R
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Inc 01.11.2012
• Subjects: Allergy and Immunology; Analgesia; Analgesics; Analgesics, Opioid - adverse effects; Animals; Central nervous system; Central Nervous System - immunology; Central Nervous System - metabolism; Chemokines; Chronic constriction injury; Cytokines; Cytokines - immunology; Cytokines - metabolism; Disease Models, Animal; Freund's adjuvant; Glia; Hyperalgesia - immunology; Hyperalgesia - metabolism; Inflammation; Inflammation - immunology; Inflammation - metabolism; Interleukin 1; Interleukin-1beta; Lipopolysaccharides; Major histocompatibility complex; Male; masseter muscle; MHC-II; Morphine; Morphine - toxicity; mRNA; Opioid; Opioid receptors; Pain; Pain - metabolism; Pain perception; Peripheral Nervous System Diseases - immunology; Peripheral Nervous System Diseases - metabolism; Peripheral neuropathy; Priming; Pro-inflammatory cytokine; Psychiatry; Rats; Rats, Sprague-Dawley; Receptor mechanisms; Sciatic nerve; Skin; Spinal cord; TLR4 protein; Toll-like receptor 4; Toll-like receptors; Tumor necrosis factor- alpha; Pro-inflammatory cytokine; Pain; Chronic constriction injury; Toll-like receptor 4; Opioid; Priming; Interleukin-1beta; Glia; MHC-II

Highlight ► Morphine dosing for five days potentiates subsequent neuroinflammation and mechanical allodynia from hindpaw inflammation, hindlimb neuropathy and orofacial inflammation.