P300-dependent STAT3 acetylation is necessary for angiotensin II-induced pro-fibrotic responses in renal tubular epithelial cells

• Published in: Acta pharmacologica Sinica Vol. 35; no. 9; pp. 1157 - 1166
• Main Authors: Ni, Jun, Shen, Yang, Wang, Zhen, Shao, De-cui, Liu, Jia, Kong, Ya-li, Fu, Lan-jun, Zhou, Li, Xue, Hong, Huang, Yu, Zhang, Wei, Yu, Chen, Lu, Li-min
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.09.2014; Nature Publishing Group
• Subjects: Acetylation - drug effects; Angiotensin II - pharmacology; Animals; Biomedical and Life Sciences; Biomedicine; Cell Line; E1A-Associated p300 Protein - metabolism; Epithelial Cells - drug effects; Epithelial Cells - metabolism; Fibrosis - chemically induced; Fibrosis - metabolism; Immunology; Internal Medicine; Kidney Tubules - drug effects; Kidney Tubules - metabolism; Medical Microbiology; Original; original-article; P300; Pharmacology/Toxicology; Rats; STAT3; STAT3 Transcription Factor - metabolism; Vaccine; 乙酰化; 依赖性; 纤维化; 肾小管上皮细胞; 血管紧张素II; 诱导作用; p300; AG490; angiotensin II; STAT3; C646; renal fibrosis; renal tubular epithelial cells; JAK2; extracellular matrix; curcumin

Aim： To explore the role of signal transducer and activator of transcription 3 （STAT3） signaling pathway, especially STAT3 acetylation, in angiotensin II （Ang II）-induced pro-fibrotic responses in renal tubular epithelial cells. Methods： Rat renal tubular epithelial cell line （NRK-52E） was used. STA...