A randomized controlled trial of antioxidant supplementation for pain relief in patients with chronic pancreatitis

• Published in: Gastroenterology (New York, N.Y. 1943) Vol. 136; no. 1; p. 149
• Main Authors: Bhardwaj, Payal, Garg, Pramod Kumar, Maulik, Subir Kumar, Saraya, Anoop, Tandon, Rakesh Kumar, Acharya, Subrat Kumar
• Format: Journal Article
• Language: English
• Published: United States 01.01.2009
• Subjects: Adult; Analgesics - administration & dosage; Antioxidants - administration & dosage; Antioxidants - adverse effects; Biomarkers; Calcium Channels; Double-Blind Method; Female; Hospitalization; Humans; Male; Nerve Tissue Proteins - antagonists & inhibitors; Oxidative Stress; Pain - drug therapy; Pancreatitis, Chronic - physiopathology; Transient Receptor Potential Channels - antagonists & inhibitors; TRPA1 Cation Channel

Oxidative stress has been implicated in the pathophysiology of chronic pancreatitis (CP). We evaluated the effects of antioxidant supplementation on pain relief, oxidative stress, and antioxidant status in patients with CP. In a placebo-controlled double blind trial, consecutive patients with CP wer...