Human mesenchymal stromal cells from adult and neonatal sources: comparative analysis of their morphology, immunophenotype, differentiation patterns and neural protein expression

• Published in: Cytotherapy (Oxford, England) Vol. 11; no. 2; pp. 163 - 176
• Main Authors: Montesinos, J.J., Flores-Figueroa, E., Castillo-Medina, S., Flores-Guzmán, P., Hernández-Estévez, E., Fajardo-Orduña, G., Orozco, S., Mayani, H.
• Format: Journal Article
• Language: English
• Published: England Elsevier Inc 01.01.2009; Informa UK Ltd
• Subjects: Adult; Advanced Basic Science; Bone Marrow Cells - cytology; Cell Differentiation; Colony-Forming Units Assay; differentiation; Female; Fetal Blood - cytology; Flow Cytometry; Gene Expression Profiling; Humans; Immunomagnetic Separation; Infant, Newborn; mesenchymal stromal cells; Mesenchymal Stromal Cells - cytology; Mesenchymal Stromal Cells - physiology; neural proteins; Other; placenta; Placenta - cytology; Pregnancy; Stromal Cells - cytology; Stromal Cells - physiology; umbilical cord blood; placenta; umbilical cord blood; differentiation; neural proteins; mesenchymal stromal cells

Bone marrow (BM) has been recognized as the main source of mesenchymal stromal cells (MSC); however, MSC have also been detected in umbilical cord blood (UCB) and placenta (PL). In the present study, we obtained MSC from these three sources and characterized them in a comparative manner. MSC were ob...