Phosphate steering by Flap Endonuclease 1 promotes 5′-flap specificity and incision to prevent genome instability - Tsutakawa, Susan E.; Thompson, Mark J.; Arvai, Andrew S.; Neil, Alexander J.; Shaw, Steven J.; Algasaier, Sana I.; Kim, Jane C.; Finger, L. David; Jardine, Emma; Gotham, Victoria J.B.; Sarker, Altaf H.; Her, Mai Z.; et al. (Nature communications, 2017)
Keywords: 60 APPLIED LIFE SCIENCES; 631/208/211; 631/45/147; 631/45/173; 631/535/1266; Amino Acid Sequence; BASIC BIOLOGICAL SCIENCES; Binding Sites; Biochemistry; Catalysis; Catalytic Domain; Crystallography; Deoxyribonucleic acid; DNA; DNA - chemistry; DNA - genetics; DNA - metabolism; DNA biosynthesis; DNA Repair; DNA Replication; Electrostatic properties; Endonuclease; FEN1 protein; Flap Endonucleases - chemistry; Flap Endonucleases - genetics; Flap Endonucleases - metabolism; Flaps; Genomes; Genomic Instability; Humanities and Social Sciences; Humans; In vitro methods and tests; Integrity; multidisciplinary; Mutation; Phosphate; Phosphates - chemistry; Phosphates - metabolism; Polarity; Replication; Residues; Science; Science (multidisciplinary); Sequence Alignment; Stability; Steering; Substrate Specificity