Systematic evaluation of differential splicing tools for RNA-seq studies

• Published in: Briefings in bioinformatics Vol. 21; no. 6; pp. 2052 - 2065
• Main Authors: Mehmood, Arfa, Laiho, Asta, Venäläinen, Mikko S, McGlinchey, Aidan J, Wang, Ning, Elo, Laura L
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.12.2020; Oxford Publishing Limited (England)
• Subjects: Biological activity; Computer applications; Data analysis; differential splicing; Evaluation; event-based methods; exon-based methods; Exons; Genes; isoform-based methods; Post-transcription; Protein Isoforms; Reproducibility of Results; Review; Ribonucleic acid; RNA; RNA Splicing; RNA-Seq; Sequence Analysis, RNA - methods; Splicing; splicing events; isoform-based methods; RNA-seq; differential splicing; splicing events; event-based methods; exon-based methods

Abstract Differential splicing (DS) is a post-transcriptional biological process with critical, wide-ranging effects on a plethora of cellular activities and disease processes. To date, a number of computational approaches have been developed to identify and quantify differentially spliced genes fro...