Comparison of Tissue Distribution, Persistence, and Molecular Epidemiology of Parvovirus B19 and Novel Human Parvoviruses PARV4 and Human Bocavirus

• Published in: The Journal of infectious diseases Vol. 195; no. 9; pp. 1345 - 1352
• Main Authors: Manning, Ashleigh, Willey, Samantha J., Bell, Jeanne E., Simmonds, Peter
• Format: Journal Article
• Language: English
• Published: Chicago, IL The University of Chicago Press 01.05.2007; University of Chicago Press
• Subjects: Acquired Immunodeficiency Syndrome - complications; Age Distribution; AIDS; Autopsies; Biological and medical sciences; Bocavirus - genetics; Bocavirus - isolation & purification; Bone marrow; Case-Control Studies; DNA; DNA Primers; DNA, Viral - analysis; England - epidemiology; Fundamental and applied biological sciences. Psychology; Genotypes; HIV; Human immunodeficiency virus; Humans; Immunocompromised Host; Infections; Infectious diseases; Major and Brief Reports; Medical sciences; Microbiology; Miscellaneous; Parvoviridae - classification; Parvoviridae - genetics; Parvoviridae - isolation & purification; Parvoviridae Infections - blood; Parvoviridae Infections - complications; Parvoviridae Infections - epidemiology; Parvoviridae Infections - virology; Parvovirus; Parvovirus B19; Parvovirus B19, Human - genetics; Parvovirus B19, Human - isolation & purification; Polymerase Chain Reaction; Tissue samples; Viral Load; Virology; Viruses; England; Virus; Human; Infection; Microbiology; Parvoviridae; Molecular epidemiology; Genotype; Erythrovirus; Virus B19; Parvovirinae

Background. PARV4 and human bocavirus (HBoV) are newly discovered human parvoviruses with poorly understood epidemiologies and disease associations. We investigated the frequencies of persistence, tissue distribution, and influence of immunosuppression on replication of these viruses. Methods. At au...