Intratumoral lymphangiogenesis of esophageal squamous cell carcinoma and relationship with regulatory factors and prognosis

• Published in: Pathology international Vol. 58; no. 10; pp. 611 - 619
• Main Authors: Inoue, Akemi, Moriya, Hiromitsu, Katada, Natsuya, Tanabe, Satoshi, Kobayashi, Nobuyuki, Watanabe, Masahiko, Okayasu, Isao, Ohbu, Makoto
• Format: Journal Article
• Language: English
• Published: Melbourne, Australia Blackwell Publishing Asia 01.10.2008
• Subjects: Carcinoma, Squamous Cell - metabolism; Carcinoma, Squamous Cell - mortality; Carcinoma, Squamous Cell - secondary; D2-40; Disease-Free Survival; Esophageal Neoplasms - metabolism; Esophageal Neoplasms - mortality; Esophageal Neoplasms - pathology; esophagus; Female; Fluorescent Antibody Technique, Indirect; Gene Expression Regulation, Neoplastic; Humans; lymph node metastasis; Lymph Nodes - pathology; Lymphangiogenesis; Lymphatic Metastasis; Lymphatic Vessels - pathology; Male; p53; Platelet-Derived Growth Factor - genetics; Platelet-Derived Growth Factor - metabolism; platelet-derived growth factor-A; prognosis; RNA, Messenger - metabolism; squamous cell carcinoma; Survival Rate; Tumor Suppressor Protein p53 - genetics; Tumor Suppressor Protein p53 - metabolism; Vascular Endothelial Growth Factor A - genetics; Vascular Endothelial Growth Factor A - metabolism; Vascular Endothelial Growth Factor C - genetics; Vascular Endothelial Growth Factor C - metabolism; vascular endothelial growth factor-A; vascular endothelial growth factor‐A, ‐C

The clinical and pathological significance of intratumoral lymphangiogenesis (ITL) with human esophageal squamous cell carcinomas (ESCC) remains unclear, as does the role of signaling molecules such as vascular endothelial growth factor (VEGF)‐A,C, platelet‐derived growth factor (PDGF)‐A, and p53, i...