Multiple myeloma: New surface antigens for the characterization of plasma cells in the era of novel agents

• Published in: Cytometry. Part B, Clinical cytometry Vol. 90; no. 1; pp. 81 - 90
• Main Authors: Muccio, Vittorio Emanuele, Saraci, Elona, Gilestro, Milena, Gattei, Valter, Zucchetto, Antonella, Astolfi, Monica, Ruggeri, Marina, Marzanati, Eleonora, Passera, Roberto, Palumbo, Antonio, Boccadoro, Mario, Omedè, Paola
• Format: Journal Article
• Language: English
• Published: United States Blackwell Publishing Ltd 01.01.2016; Wiley Subscription Services, Inc
• Subjects: Aged; Aged, 80 and over; Antibodies - chemistry; Antibody Specificity; Antigens, CD - analysis; Antigens, CD - genetics; Antigens, CD - immunology; Biomarkers, Tumor - analysis; Biomarkers, Tumor - genetics; Biomarkers, Tumor - immunology; Case-Control Studies; CD150; CD272; Clone Cells; Female; Flow Cytometry - standards; Fluorescent Dyes - chemistry; Gene Expression; Humans; Immunophenotyping - standards; Leukemia; Leukemia, Plasma Cell - diagnosis; Leukemia, Plasma Cell - immunology; Leukemia, Plasma Cell - pathology; Male; Middle Aged; Multiple myeloma; Multiple Myeloma - diagnosis; Multiple Myeloma - immunology; Multiple Myeloma - pathology; plasma cell immunophenotype; Plasma Cells - immunology; Plasma Cells - pathology; Reproducibility of Results; SLAM; plasma cell immunophenotype; multiple myeloma; CD272; SLAM; CD150

ABSTRACT Background Multiple Myeloma (MM) is a neoplastic disorder characterized by clonal proliferation of malignant plasma cells (PCs). Flow cytometry is an essential tool to confirm diagnosis and evaluate minimal residual disease (MRD). This study aims at identifying new surface PC markers suitab...