The mitochondrial transcription factor TFAM in neurodegeneration: emerging evidence and mechanisms

• Published in: FEBS letters Vol. 592; no. 5; pp. 793 - 811
• Main Authors: Kang, Inhae, Chu, Charleen T., Kaufman, Brett A.
• Format: Journal Article
• Language: English
• Published: England 01.03.2018
• Subjects: Animals; DNA Copy Number Variations; DNA Replication; DNA, Mitochondrial - biosynthesis; DNA, Mitochondrial - genetics; DNA-Binding Proteins - genetics; DNA-Binding Proteins - metabolism; Genome, Mitochondrial; homeostasis; Humans; inflammation; Inflammation - genetics; Inflammation - metabolism; Inflammation - pathology; mitochondria; mitochondrial DNA; mitochondrial genome; Mitochondrial Proteins - genetics; Mitochondrial Proteins - metabolism; neurodegeneration; neurodegenerative diseases; Neurodegenerative Diseases - genetics; Neurodegenerative Diseases - metabolism; Neurodegenerative Diseases - pathology; Signal Transduction; TFAM; transcription factors; Transcription Factors - genetics; Transcription Factors - metabolism; transcription initiation; Transcription Initiation, Genetic; neurodegeneration; TFAM; mitochondrial DNA

The mitochondrial transcription factor A, or TFAM, is a mitochondrial DNA (mtDNA)‐binding protein essential for genome maintenance. TFAM functions in determining the abundance of the mitochondrial genome by regulating packaging, stability, and replication. More recently, TFAM has been shown to play...