Enhanced binding of the N501Y‐mutated SARS‐CoV‐2 spike protein to the human ACE2 receptor: insights from molecular dynamics simulations

• Published in: FEBS letters Vol. 595; no. 10; pp. 1454 - 1461
• Main Authors: Luan, Binquan, Wang, Haoran, Huynh, Tien
• Format: Journal Article
• Language: English
• Published: England John Wiley and Sons Inc 01.05.2021
• Subjects: ACE2; antibody; humans; hydrophobicity; molecular dynamics; mutation; N501Y; peptidyl-dipeptidase A; Research Letter; SARS‐CoV‐2; Severe acute respiratory syndrome coronavirus 2; spike protein; ACE2; N501Y; SARS-CoV-2; antibody; spike protein

Recently, severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) variants (B.1.1.7 and B.1351) have emerged harbouring mutations that make them highly contagious. The N501Y mutation within the receptor‐binding domain (RBD) of the spike protein of these SARS‐CoV‐2 variants may enhance binding t...