Mitochondrial DNA damage and reactive oxygen species in neurodegenerative disease

• Published in: FEBS letters Vol. 592; no. 5; pp. 728 - 742
• Main Authors: Nissanka, Nadee, Moraes, Carlos T.
• Format: Journal Article
• Language: English
• Published: England 01.03.2018
• Subjects: Animals; central nervous system; DNA Damage; DNA, Mitochondrial - genetics; DNA, Mitochondrial - metabolism; Humans; mice; mitochondria; mitochondrial DNA; neurodegeneration; neurodegenerative diseases; Neurodegenerative Diseases - genetics; Neurodegenerative Diseases - metabolism; Neurodegenerative Diseases - pathology; neurons; Oxidative Phosphorylation; reactive oxygen species; Reactive Oxygen Species - metabolism; neurodegeneration; mitochondrial DNA; reactive oxygen species

Mitochondria are essential organelles within the cell where most ATP is produced through oxidative phosphorylation (OXPHOS). A subset of the genes needed for this process are encoded by the mitochondrial DNA (mtDNA). One consequence of OXPHOS is the production of mitochondrial reactive oxygen specie...