Induced Pluripotent Stem Cells Enable Disease Modeling and Drug Screening in Calreticulin del52 and ins5 Myeloproliferative Neoplasms

• Published in: HemaSphere Vol. 5; no. 7; pp. e593 - n/a
• Main Authors: Secardin, Lise, Gomez Limia, Cintia, Silva‐Benedito, Suzana, Lordier, Larissa, El‐Khoury, Mira, Marty, Caroline, Ianotto, Jean‐Christophe, Raslova, Hana, Constantinescu, Stefan N., Bonamino, Martín Hernán, Vainchenker, William, Monte‐Mor, Barbara, Di Stefano, Antonio, Plo, Isabelle
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA Lippincott Williams & Wilkins 01.07.2021; Lippincott, Williams & Wilkins; Wiley
• Subjects: Life Sciences

Mutations in the calreticulin (CALR) gene are seen in about 30% of essential thrombocythemia and primary myelofibrosis patients. To address the contribution of the human CALR mutants to the pathogenesis of myeloproliferative neoplasms (MPNs) in an endogenous context, we modeled the CALRdel52 and CAL...