Genotyping of the cagA gene of Helicobacter pylori on immunohistochemistry with East Asian CagA-specific antibody

• Published in: Pathology international Vol. 58; no. 4; pp. 218 - 225
• Main Authors: Kanada, Ryoko, Uchida, Tomohisa, Tsukamoto, Yoshiyuki, Nguyen, Lam Tung, Hijiya, Naoki, Matsuura, Keiko, Kodama, Masaaki, Okimoto, Tadayoshi, Murakami, Kazunari, Fujioka, Toshio, Yanagisawa, Shigetaka, Moriyama, Masatsugu
• Format: Journal Article
• Language: English
• Published: Melbourne, Australia Blackwell Publishing Asia 01.04.2008
• Subjects: Amino Acid Motifs - genetics; Amino Acid Sequence; Antibody Specificity; Antigens, Bacterial - chemistry; Antigens, Bacterial - genetics; Antigens, Bacterial - immunology; Bacterial Proteins - chemistry; Bacterial Proteins - genetics; Bacterial Proteins - immunology; Biomarkers - metabolism; CagA; EPIYA motif; Gastric Mucosa - metabolism; Gastric Mucosa - microbiology; Gastric Mucosa - pathology; Genes, Bacterial; Genotype; Helicobacter Infections - diagnosis; Helicobacter Infections - metabolism; Helicobacter Infections - microbiology; Helicobacter pylori; Helicobacter pylori - genetics; Helicobacter pylori - immunology; Helicobacter pylori - isolation & purification; Humans; Immunohistochemistry; Molecular Sequence Data; Polymorphism, Genetic; Sequence Analysis, DNA

The cytotoxin‐associated antigen A (CagA) of Helicobacter pylori prevalent in East Asian countries, where the mortality rate due to gastric cancer is high, has been reported to be structurally different from that in Western countries, where the gastric cancer mortality rate is relatively low. Based...