Reticulon Short Hairpin Transmembrane Domains Are Used to Shape ER Tubules

• Published in: Traffic (Copenhagen, Denmark) Vol. 12; no. 1; pp. 28 - 41
• Main Authors: Zurek, Nesia, Sparks, Lenore, Voeltz, Gia
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.01.2011
• Subjects: Amino Acid Sequence; Animals; caveolin; Cercopithecus aethiops; COS Cells; Endoplasmic Reticulum - chemistry; Humans; membrane curvature; Membrane Proteins; Models, Biological; Molecular Sequence Data; Myelin Proteins - chemistry; Myelin Proteins - metabolism; Nogo Proteins; Protein Structure, Tertiary; reticulon; transmembrane domains; tubules

Reticulons are integral membrane proteins that partition into and shape the tubular endoplasmic reticulum (ER). We propose that reticulons use a membrane insertion mechanism to generate regions of high membrane curvature in the ER. A reticulon contains two short hairpin transmembrane domains (TMDs),...