Selective toxicity of persian gulf sea cucumber holothuria parva on human chronic lymphocytic leukemia b lymphocytes by direct mitochondrial targeting

• Published in: Environmental toxicology Vol. 32; no. 4; pp. 1158 - 1169
• Main Authors: Salimi, Ahmad, Motallebi, Abbasali, Ayatollahi, Maryam, Seydi, Enayatollah, Mohseni, Ali Reza, Nazemi, Melika, Pourahmad, Jalal
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.04.2017
• Subjects: adults; Aged; Aged, 80 and over; Animals; antineoplastic agents; Antineoplastic Agents - pharmacology; apoptosis; Apoptosis - drug effects; B lymphocyte; B-lymphocytes; B-Lymphocytes - drug effects; B-Lymphocytes - physiology; Case-Control Studies; caspase-3; Cell Survival; chronic lymphocytic leukemia; cytochrome c; Cytochromes c - metabolism; cytotoxicity; Drug Screening Assays, Antitumor; Female; Holothuria; Holothuria - chemistry; Holothuria parva; Holothurioidea; Humans; Indian Ocean; isolated mitochondria; Leukemia - drug therapy; Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy; lymphocytic leukemia; Male; marine environment; membrane potential; Membrane Potential, Mitochondrial - drug effects; Middle Aged; mitochondria; Mitochondria - drug effects; Mitochondria - metabolism; mitochondrial membrane; Mitochondrial Swelling - drug effects; Persian Gulf; pharmacodynamics; reactive oxygen species; Reactive Oxygen Species - metabolism; sea cucumber; toxicity testing; Tumor Cells, Cultured; Persian Gulf; B lymphocyte; Holothuria parva; chronic lymphocytic leukemia; isolated mitochondria; sea cucumber

ABSTRACT Natural products isolated from marine environment are well known for their pharmacodynamic potential in diversity of disease treatments such as cancer or inflammatory conditions. Sea cucumbers are one of the marine animals of the phylum Echinoderm. Many studies have shown that the sea cucum...