Selective toxicity of persian gulf sea cucumber holothuria parva on human chronic lymphocytic leukemia b lymphocytes by direct mitochondrial targeting - Salimi, Ahmad; Motallebi, Abbasali; Ayatollahi, Maryam; Seydi, Enayatollah; Mohseni, Ali Reza; Nazemi, Melika; Pourahmad, Jalal (Environmental toxicology, 2017)
Keywords: adults; Aged; Aged, 80 and over; Animals; antineoplastic agents; Antineoplastic Agents - pharmacology; apoptosis; Apoptosis - drug effects; B lymphocyte; B-lymphocytes; B-Lymphocytes - drug effects; B-Lymphocytes - physiology; Case-Control Studies; caspase-3; Cell Survival; chronic lymphocytic leukemia; cytochrome c; Cytochromes c - metabolism; cytotoxicity; Drug Screening Assays, Antitumor; Female; Holothuria; Holothuria - chemistry; Holothuria parva; Holothurioidea; Humans; Indian Ocean; isolated mitochondria; Leukemia - drug therapy; Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy; lymphocytic leukemia; Male; marine environment; membrane potential; Membrane Potential, Mitochondrial - drug effects; Middle Aged; mitochondria; Mitochondria - drug effects; Mitochondria - metabolism; mitochondrial membrane; Mitochondrial Swelling - drug effects; Persian Gulf; pharmacodynamics; reactive oxygen species; Reactive Oxygen Species - metabolism; sea cucumber; toxicity testing; Tumor Cells, Cultured; Persian Gulf; B lymphocyte; Holothuria parva; chronic lymphocytic leukemia; isolated mitochondria; sea cucumber