Immune response and long-term clinical outcome in advanced melanoma patients vaccinated with tumor-mRNA-transfected dendritic cells

• Published in: Oncoimmunology Vol. 5; no. 11; p. e1232237
• Main Authors: Kyte, Jon Amund, Aamdal, Steinar, Dueland, Svein, Sæbøe-Larsen, Stein, Inderberg, Else Marit, Madsbu, Ulf Erik, Skovlund, Eva, Gaudernack, Gustav, Kvalheim, Gunnar
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.11.2016
• Subjects: Cancer vaccine; clinical outcome; dendritic cell; melanoma; mRNA; Original Research; survival; T cell; Cancer vaccine; clinical outcome; T cell; survival; melanoma; mRNA; dendritic cell

The most effective anticancer immune responses are probably directed against patient-specific neoantigens. We have developed a melanoma vaccine targeting this individual mutanome based on dendritic cells (DCs) loaded with autologous tumor-mRNA. Here, we report a phase I/II trial evaluating toxicity,...