Structure-Function Relationship Between Corneal Nerves and Conventional Small-Fiber Tests in Type 1 Diabetes

• Published in: Diabetes care Vol. 36; no. 9; pp. 2748 - 2755
• Main Authors: Sivaskandarajah, Gavasker A., Halpern, Elise M., Lovblom, Leif E., Weisman, Alanna, Orlov, Steven, Bril, Vera, Perkins, Bruce A.
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.09.2013
• Subjects: Adult; Aged; Biological and medical sciences; Care and treatment; Complications and side effects; Cornea; Cornea - innervation; Cornea - pathology; Diabetes; Diabetes Mellitus, Type 1 - pathology; Diabetes. Impaired glucose tolerance; Diabetic Neuropathies - pathology; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Female; Heart rate; Humans; Male; Medical sciences; Metabolic diseases; Microscopy, Confocal; Middle Aged; Miscellaneous; Morphology; Optic nerve; Original Research; Physiological aspects; Polyneuropathies; Public health. Hygiene; Public health. Hygiene-occupational medicine; Regression analysis; Type 1 diabetes; Young Adult; Canada; Endocrinopathy; Human; Immunopathology; Corneal nerve; Nutrition; Type 1 diabetes; Exploration; Autoimmune disease; Metabolic diseases; Nerve fiber; Structure function relationship; Endocrinology

In vivo corneal confocal microscopy (IVCCM) has been proposed as a noninvasive technique to assess small nerve fiber structural morphology. We investigated the structure-function relationship of small fibers in diabetic sensorimotor polyneuropathy (DSP). Ninety-six type 1 diabetic subjects with a sp...