Epigenomic priming of immune genes implicates oligodendroglia in multiple sclerosis susceptibility

• Published in: Neuron (Cambridge, Mass.) Vol. 110; no. 7; pp. 1193 - 1210.e13
• Main Authors: Meijer, Mandy, Agirre, Eneritz, Kabbe, Mukund, van Tuijn, Cassandra A., Heskol, Abeer, Zheng, Chao, Mendanha Falcão, Ana, Bartosovic, Marek, Kirby, Leslie, Calini, Daniela, Johnson, Michael R., Corces, M. Ryan, Montine, Thomas J., Chen, Xingqi, Chang, Howard Y., Malhotra, Dheeraj, Castelo-Branco, Gonçalo
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 06.04.2022
• Subjects: Animals; Cell Differentiation - physiology; chromatin; Chromatin - metabolism; Epigenomics; genome-wide association studies; histone modifications; Interferon-gamma - genetics; major histocompatibility complex; Mice; multiple sclerosis; Multiple Sclerosis - genetics; Multiple Sclerosis - metabolism; myelin; Myelin Sheath - metabolism; neuroimmunology; oligodendrocyte; Oligodendroglia - metabolism; Polycomb; single-nucleotide polymorphisms; myelin; neuroimmunology; multiple sclerosis; oligodendrocyte; Polycomb; histone modifications; major histocompatibility complex; chromatin; single-nucleotide polymorphisms; genome-wide association studies

Multiple sclerosis (MS) is characterized by a targeted attack on oligodendroglia (OLG) and myelin by immune cells, which are thought to be the main drivers of MS susceptibility. We found that immune genes exhibit a primed chromatin state in single mouse and human OLG in a non-disease context, compat...